Results 131 to 140 of about 34,072 (291)

Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation [PDF]

, 2014
Purpose The clinical phenotype of advanced stage retinopathy of prematurity (ROP, stages 4 and 5) cannot be replicated in an animal model. To dissect the molecular events that can lead up to advanced ROP, we examined subretinal fluid (SRF) and surgically
Cyr, Desireé, Hirose, Tatsuo, Lam, Godfrey, Lashkari, Kameran, Ma, Jie, Mehta, Manisha, Ng, Tat Fong, Tawansy, Khaled A., Taylor, Andrew W.   +8 more
core  

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science, EarlyView.
This study develops the hydrogel with antimicrobial, adhesive, degradable, injectable, and temperature‐sensitive contraction properties based on the transcriptomic and pathological characteristics of intestinal fistula patients. This hydrogel can seal rabbit intestinal fistula in situ, reduce the intestinal defect, and promote intestinal epithelial ...
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
wiley   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

Advanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen   +9 more
wiley   +1 more source

Intravitreal ranibizumab (Lucentis®) for the treatment of myopic choroidal neovascularization [PDF]

, 2018
Background: Macular choroidal neovascularization (CNV) is one of the most vision-threatening complications of myopia, which can lead to severe vision loss.
Ambresin, Aude, Konstantinidis, Lazaros, Mantel, Irmela, Pournaras, Jean-Antoine, Zografos, Leonidas   +4 more
core  

Transcriptomics Guided Engineering of Exosome‐Encapsulated Bifunctional Nanosheets Targeting the Immune‐PI3K/Akt Axis for Osteoporosis Therapy

Advanced Science, EarlyView.
A multifunctional nanosheet–exosome hybrid system incorporating f‐CA(OH) nanosheets enriched with abundant surface vacancies are developed. These nanosheets fuse with natural exosomes, endowing them with nanozyme‐like catalytic capabilities while retaining their inherent biological functions.
Rongze Tang, Guanhong Liu, Congcong Wang, Minghao Chao, Guangyu Ma, Pengjin Wei, Siling Du, Junjie Li, Yufan Liu, Chaonan Jing, Guoquan Wu, Ming Guan, Hongliang Chen, Fenglei Gao   +13 more
wiley   +1 more source

Treatment of myopic choroidal neovascularization with intravitreal ranibizumab injections: the role of age

Clinical Ophthalmology, 2017
Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Konstantinos Kaprinis,1 Athanassios Giarmoukakis,2 lias Georgalas,3 Efstratios A Parikakis,1 Miltiadis K Tsilimbaris2 1Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology,
Karagiannis D, Kontadakis GA, Kaprinis K, Giarmoukakis A, Georgalas I, Parikakis EA, Tsilimbaris MK   +6 more
doaj  

Immunoregulatory Roles of Tumor‐Originated Pericytes Identified by Single‐Cell Analysis in Glioblastoma

Advanced Science, EarlyView.
The origin and functional heterogeneity of pericytes in glioblastoma (GBM) remain unclear. This study identifies tumor‐originated pericytes (T‐PCs) and normal‐originated pericytes as two distinctive populations in human GBM using single‐cell RNA‐sequencing.
Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu, Jianghong Man, Wei Wang, Dongxue Li, Xiu‐wu Bian, Hai‐bo Wu, Aili Zhang, Wenchao Zhou   +16 more
wiley   +1 more source

Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration [PDF]

, 2018
Agarwal, Betel, Dong, Gehlbach, Gerrity, Gerrity, Ménard, Nakamura, Paraskevopoulou, Peled, Vlachos, Wong   +11 more
core   +2 more sources

NO‐Driven Janus Nanomotor Enhances T‐Cell Infiltration by Reconstructing Tumor‐Associated Blood and Lymphatic Vessels

Advanced Science, EarlyView.
NO‐driven hollow gold Janus nanomotors (HAM) are engineered to improve tumor blood vessel normalization throughout the entire tumor region to enhance T‐cell intratumoral infiltration, and generate and capture whole‐tumor antigens as an in situ cancer vaccine to enhance T‐cell activation, therefore enhancing the antitumor immune response.
Qingping Ma, Shunli Fu, Yiming Xia, Shuying Gao, Zhenxing Xia, Panpan Gu, Shijun Yuan, Jinhu Liu, Shuang Liang, Nan Li, Qinglin Yang, Weiwei Mu, Jie Liu, Xinrui Liu, Yongjun Liu, Na Zhang   +15 more
wiley   +1 more source

Nanozyme‐Engineered Probiotic Microneedle Patch for Chronic Diabetic Wound Therapy

Advanced Science, EarlyView.
This work introduces a robust living‐materials‐based strategy that integrates microbial therapy with catalytic nanotechnology for effective management of chronic infected wounds via alleviating reactive oxygen species (ROS), combating bacterial infection, relieving hypoxia, and exerting anti‐inflammatory effects.
Xueyang Wang, Shuhua Liu, Shisuo Jing, Siyu Zhang, Yinli Jin, Wen Zhang, Qiongfang Ruan, Wei Li   +7 more
wiley   +1 more source