Results 131 to 140 of about 34,616 (291)

Mixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models [PDF]

, 2009
peer reviewedBACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature
A. Beliard, Abulafia, Asahara, Becker, BRUNER-TRAN, C. Galant, Critchley, Debbage, Di Carlo, Donnez, E. Marbaix, Eggermont, F. Frankenne, Fraser, Galili, Galili, Gargett, Gordon, Grummer, Hickey, Hull, J.-M. Foidart, Jaffe, Kawashima, KRIKUN, M. Nisolle, M.-L. Alvarez Gonzalez, McCluggage, Mints, Murphy, Nap, Nisolle, Pe a, Risau, Rydberg, Saito, Smith, Story, Van Cauwenberge, Zeng   +39 more
core   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy [PDF]

, 2016
Diabetic retinopathy (DR) affects approximately one-third of diabetic patients and, if left untreated, progresses to proliferative DR (PDR) with associated vitreous hemorrhage, retinal detachment, iris neovascularization, glaucoma and irreversible ...
Bassuk, Alexander G., Grant, Maria B., Hsu, Chun Wei, Janisch, Kerstin M., Li, Yao, Mahajan, MaryAnn, Mahajan, Minit B., Nagasaki, Takayuki, Tosi, Joaquin, Tsang, Stephen H., Wert, Katherine, Yan, Yuanqing, Zhang, Lijuan   +12 more
core   +2 more sources

β-LGND2, an ERβ Selective Agonist, Inhibits Pathologic Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2012
The goal of our study was to evaluate the in vitro and in vivo anti-angiogenic effects of ERβ selective agonist, β-LGND2, using human retinal microvascular endothelial cell (HRMVEC) cultures and a mouse model for oxygen-induced retinopathy (OIR).The selectivity of β-LGND2 was determined using binding and transactivation assays.
Anand, Giddabasappa, Jeetendra R, Eswaraka, Christina M, Barrett, Matthew N, Bauler, Zhongzhi, Wu, Muralimohan, Yepuru, Duane D, Miller, James T, Dalton   +7 more
openaire   +2 more sources

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Stem Cell Therapy for Retinopathy of Prematurity [PDF]

, 2013
Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness that severely affecting the quality of life of these children. Few treatment options are available but without favorable outcomes.
Fu, ZJ, Lai, AKW, Lo, ACY
core   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Comparación de las tasas de progresión de la maculopatía miópica entre población caucásica y asiática [PDF]

, 2019
Describir el patrón y calcular la tasa de progresión de la Maculopatía Miópica en una serie española de pacientes con Miopía Patológica y comparar los resultados con los de una serie japonesa.
Fuente Gómez, Daniel de la
core  

DNA‐Inspired Multi‐Functional Double‐Cross‐Linking Self‐Healing Hydrogel Promotes the Healing of Diabetic Wounds

Advanced Science, EarlyView.
A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang, Yue Hu, Yikun Ju, Naihsin Hsiung, Juyi Ye, Anquan Jian, Lanjie Lei, Bairong Fang   +7 more
wiley   +1 more source