Results 31 to 40 of about 150,746 (305)

The Durability of Vaccine Efficacy against Ocular HSV-1 Infection Using ICP0 Mutants 0∆NLS and 0∆RING Is Lost over Time

Pathogens, 2021
Vaccines to viral pathogens in experimental animal models are often deemed successful if immunization enhances resistance of the host to virus challenge as measured by cumulative survival, reduction in virus replication and spread and/or lessen or ...
Daniel J. J. Carr, Amanda Berube, Edward Gershburg   +2 more
doaj   +1 more source

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis

Frontiers in Immunology, 2022
Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population.
Tian Yu, Tian Yu, Fabian Schuette, Maria Christofi, John V. Forrester, John V. Forrester, John V. Forrester, Gerard J. Graham, Lucia Kuffova, Lucia Kuffova   +9 more
doaj   +1 more source

Microglial TSPAN4-Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune-Vascular Crosstalk. [PDF]

Adv Sci (Weinh)
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Xu J, Wang J, Ge P, Gu Q, Li H, Fan Y, Xie H, Lu Y, Lin Y, Wu X, Wang C, Xie P, Hu Z.   +12 more
europepmc   +2 more sources

EFFICIENCY OF AFLIBERCEPT IN CLINICAL PRACTICE

Офтальмохирургия, 2017
Introduction. Age-related macular degeneration is a leading cause of severe vision loss worldwide, frequently resulting in legal blindness. Implementation of anti-VEGF therapy in clinical practice was an important milestone in the treatment of age ...
A. V. Kulagina
doaj   +1 more source

Metabolism in Retinopathy of Prematurity

Life, 2021
Retinopathy of prematurity is defined as retinal abnormalities that occur during development as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth.
Yohei Tomita, Ayumi Usui-Ouchi, Anders K. Nilsson, Jay Yang, Minji Ko, Ann Hellström, Zhongjie Fu   +6 more
doaj   +1 more source

Vascular Morphogenesis in the Context of Inflammation: Self-Organization in a Fibrin-Based 3D Culture System

Frontiers in Physiology, 2018
Introduction: New vessel formation requires a continuous and tightly regulated interplay between endothelial cells with cells of the perivascular microenvironment supported by mechanic-physical and chemical cues from the extracellular matrix.Aim: Here we
Beate M. Rüger, Tanja Buchacher, Alexander Giurea, Bernd Kubista, Michael B. Fischer, Michael B. Fischer, Johannes M. Breuss   +6 more
doaj   +1 more source

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Cells, 2022
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal   +9 more
doaj   +1 more source

Nanomedicine Approaches for Corneal Diseases

Journal of Functional Biomaterials, 2015
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions.
Shyam S. Chaurasia, Rayne R. Lim, Rajamani Lakshminarayanan, Rajiv R. Mohan   +3 more
doaj   +1 more source

Inflammatory Choroidal Neovascularization [PDF]

Ocular Immunology and Inflammation, 2020
Inflammatory choroidal neovascularization (iCNV) is an uncommon complication of uveitis resulting from direct involvement of the retinal pigment epithelium (RPE)-Bruch’s membrane complex by inflamm...
Emmett T, Cunningham, Francesco, Pichi, Rosa, Dolz-Marco, K Bailey, Freund, Manfred, Zierhut   +4 more
openaire   +2 more sources

Lipid Signaling in Ocular Neovascularization

, 2020
Vasculogenesis and angiogenesis play a crucial role in embryonic development. Pathological neovascularization in ocular tissues can lead to vision-threatening vascular diseases, including proliferative diabetic retinopathy, retinal vein occlusion ...
Ryo Terao, Hiroki Kaneko
core   +1 more source