Results 51 to 60 of about 136,412 (260)

Ferrochelatase regulates retinal neovascularization

, 2020
Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo.
Pran Babu, Sardar Pasha Sheik, White, Darcy, Corson, Timothy W.   +2 more
core   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Neovascularization in Purtscher's retinopathy

, 2011
Annie Chan, Douglas R Fredrick, Theodore Leng Department of Ophthalmology, Byers Eye Institute at Stanford University, Stanford University School of Medicine, Stanford, CA, USA Abstract: We report a case of neovascularization secondary to Purtscher& ...
Leng T, Chan A, Fredrick DR
core  

PRECURSORS OF TYPE 3 NEOVASCULARIZATION

, 2013
PURPOSE: To study the advent of exudative age-related macular degeneration in uninvolved fellow eyes of patients with unilateral Type 3 neovascularization and to investigate the precursors at the site of lesion development.
Giuseppe Querques, Rocio Blanco, FORTE, RAIMONDO, Lea Querques, Nathalie Massamba, Eric H. Souied   +5 more
core   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Bevacizumab for the Treatment of Corneal Neovascularization

, 2011
Corneal neovascularization (NV) is a severe complication associated with inflammatory or infectious disorders of the cornea. NV may lead to severe reduction in visual acuity and poor prognosis for corneal transplantation and excimer laser refractive ...
CHEN, WEI-LI;CHEN, YAN-MING;CHU, HSIAO-SANG;TSAI, TZU-YUN;HU, FUNG-RONG, 陳偉勵;陳彥名;朱筱桑;蔡紫筠;胡芳蓉   +1 more
core  

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Choroidal neovascularization secondary to Best’s vitelliform macular dystrophy in two siblings of a Malay family

, 2014
Koh Alisa-Victoria,1 Tan Jin-Poi,1 Ismail Shatriah,1 Embong Zunaina,1 Nor Fariza Ngah2 1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 2Department of Ophthalmology, Hospital Selayang ...
Zunaina E, Jin-Poi T,Shatriah I, Ngah NF, Alisa-Victoria K   +3 more
core  

Lactadherin promotes VEGF-dependent neovascularization

, 2005
International audienceVascular endothelial growth factor (VEGF)-induced blood vessel growth is involved in both physiological and pathological angiogenesis and requires integrin-mediated signaling.
Jean-Sébastien Silvestre, Sylvia Heeneman, Christophe Houbron, Silvestre, J.-S., Alain Delcayre, Hamard, G., Mallat, Z., Olivier Blanc-Brude, Heeneman, S., Alain Tedgui, Tedgui, A., Théry, C., Radia Tamarat, Micheline Duriez, Aguilar, B., Boddaert, J., Tamarat, R., Sebastian Amigorena, Bernard Lévy, Jacques Boddaert, Delcayre, A., Houbron, C., Régine Merval, Ghislaine Hamard, Duriez, M., Amigorena, S., Ziad Mallat, Michel Clergue, Barbara Aguilar, Blanc-Brude, O., Clotilde Théry, Clergue, M., Lévy, B., Merval, R.   +33 more
core   +1 more source