Results 1 to 10 of about 35,226 (335)

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Zaheer Ali, Anthony Mukwaya, Antje Biesemeier, Maria Ntzouni, Daniel Ramsköld, Sarantis Giatrellis, Parviz Mammadzada, Renhai Cao, Anton Lennikov, Michele Marass, Claudia Gerri, Camilla Hildesjö, Michael R. Taylor, Qiaolin Deng, Beatrice Peebo, Luis del Peso, Anders Kvanta, Rickard Sandberg, Ulrich Schraermeyer, Helder André, J. F. Steffensen, Neil Lagali, Yihai Cao, Julianna Kele, Lasse D. Jensen   +24 more
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Factors associated with the recurrence of choroidal neovascularization in pathologic myopia [PDF]

Frontiers in Medicine, 2022
PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing, Yuxia Bo, Lei Gao, Zhen Wang   +3 more
doaj   +2 more sources

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

Communications Medicine, 2021
Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee, Soohyun Kim, Dong Hyun Jo, Chang Sik Cho, Su Ree Kim, Dongmin Kang, Jisu Chae, Duck Kyun Yoo, Suji Ha, Junho Chung, Jeong Hun Kim   +10 more
doaj   +2 more sources

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Brunken, William J., Crespo-Garcia, Sergio, Joussen, Antonia M., Klein, Sabrina V., Koch, Manuel, Kociok, Norbert, Liang, Yong, Maier, Anna-Karina, Moritz, Eva, Nürnberg, Christina, Reichhart, Nadine, Skosyrski, Sergej, Strauß, Olaf   +12 more
core   +6 more sources

RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization

Journal of Vascular Research, 2023
Objective: The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro. Methods: C57BL/6 was used to establish an OIR model. First, RhoA/ROCK expression was first examined and compared between OIR and healthy controls. Then, we evaluated the effect of Fasudil on
Fen Tang, Kongqian Huang, Biyan Peng, Wen Deng, Ning Su, Fan Xu, Mingyuan Zhang, Haibin Zhong   +7 more
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Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia

romanian journal of ophthalmology, 2020
Purpose: To evaluate the incidence of choroidal neovascularization (CNV) in high myopic patients who experienced recent visual loss and to describe the characteristics of CNV that develop as a complication of pathologic myopia and were detected by fluorescein angiography (FA).
Anca Tomi, Irina Ștefan
openalex   +4 more sources

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization [PDF]

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +3 more sources

Choroidal Changes and Choroidal Neovascularization in Pathological Myopia [PDF]

Güncel Retina Dergisi (Current Retina Journal)
Among the complications of pathological myopia, myopic macular neovascularization (mMNV) is one of the most vision-threatening complications. Despite significant advances in understanding the epidemiology, pathogenesis, and natural history of the disease, there is no standard definition of mMNV.
Semra Koca, Mutluay Bozoklu
openalex   +2 more sources

The lipid ratio castelli’s risk index II is a novel biomarker for intraplaque neovascularization in patients with carotid stenosis [PDF]

Lipids in Health and Disease
Background Dyslipidemia is a well-established cause of atherosclerosis. Intraplaque neovascularization (IPN), a hallmark of vulnerable stroke-prone plaques, is a critical feature of dyslipidemia progression.
Liuping Cui, Fubo Zhou, Ying Chen, Ran Liu, Yingqi Xing   +4 more
doaj   +2 more sources

Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading ...
Thaís Heinke, Kleber Simões do Espiríto Santo, Adhemar Longatto Filho, João Norberto Stavale   +3 more
doaj   +3 more sources