Results 21 to 30 of about 26,345 (302)
Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]
Trends in Molecular Medicine, 2018 Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
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Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3 [PDF]
EBioMedicine, 2021 Pathological neovascularization in neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss in the elderly. Increasing evidence shows that cells of myeloid lineage play important roles in controlling pathological endothelium formation.
Tianxi Wang +8 more
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BMC Molecular and Cell Biology, 2020 Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai +4 more
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Communications Medicine, 2021 Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee +10 more
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Sema3f Protects Against Subretinal Neovascularization In Vivo
EBioMedicine, 2017 Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti ...
Ye Sun +17 more
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Angiogenesis in squamous precancerous cervical lesions [PDF]
Vojnosanitetski Pregled, 2007 Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between
Panjković Milan +1 more
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Irisin Attenuates Pathological Neovascularization in Oxygen-Induced Retinopathy Mice
Investigative Opthalmology & Visual Science, 2022 Abnormal angiogenesis is a defining feature in a couple of ocular neovascular diseases. The application of anti-VEGFA therapy has achieved certain benefits in the clinic, accompanying side effects and poor responsiveness in many patients. The present study investigated the role of irisin in retinal neovascularization.Western blot and quantitative PCR ...
Zhang, Jieqiong +8 more
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International Journal of Ophthalmology, 2013 Choroidal neovascularization (CNV) is an uncommon complication associated with a macular hole. In this case report of a rare condition, we present a pathologic myopia patient with a co-existent macular hole and choroidal neovascular membrane. The patient
Zhi-Qing Chen +4 more
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El cáncer en la función mitocondrial
Revista de la Facultad de Medicina, 2018 Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to
Sofía Isabel Freyre-Bernal +4 more
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Antioxidants, 2021 Although the exact pathogenetic mechanisms leading to age-related macular degeneration (AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an imbalance between local oxidants/anti-oxidant systems leading to chronic ...
Caterina Toma +4 more
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