Results 11 to 20 of about 134,203 (255)

Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis. The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.C57BL/6 neonatal mice ...
Shingo, Satofuka, Atsuhiro, Ichihara, Norihiro, Nagai, Takashi, Koto, Hajime, Shinoda, Kousuke, Noda, Yoko, Ozawa, Makoto, Inoue, Kazuo, Tsubota, Hiroshi, Itoh, Yuichi, Oike, Susumu, Ishida   +11 more
openaire   +3 more sources

VISUAL ACUITY OUTCOMES OF RANIBIZUMAB TREATMENT IN PATHOLOGIC MYOPIC EYES WITH MACULAR RETINOSCHISIS AND CHOROIDAL NEOVASCULARIZATION [PDF]

, 2016
PURPOSE To investigate visual and morphological outcome in eyes with MRS and choroidal neovascularization (CNV) secondary to pathologic myopia treated with intravitreal (IVT) ranibizumab. METHODS Post hoc analysis of the patients included in the
Ceklic, Lala, Gekkieva, Margarita, Munk, Marion, Wolf-Schnurrbusch, Ute, Wolf, Sebastian, Wolf S, Ceklic L, Wolf-Schnurrbusch U, Munk MR, Gekkieva M   +9 more
core   +3 more sources

Antibody-drug conjugate (Pathologic ocular neovascularization in mouse models)

, 2021
Immunofluorescence staining of whole-mount retinas and retinal pigment epithelium-choroid-scleral complexes, electroretinography, and OptoMotry test were used to evaluate the effect and safety of ADC targeting mPDGFRβ in the mouse models of pathologic ...
Su Ree Kim, Jisu Chae, Seok Jae Lee, Soohyun Kim, Duck Kyun Yoo, Suji Ha, Dong Hyun Jo, Chang Sik Cho, Dongmin Kang, Jeong Hun Kim, Junho Chung   +10 more
core   +1 more source

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

, 2021
BACKGROUND: Crosstalk between pericytes and endothelial cells is critical for ocular neovascularization. Endothelial cells secrete platelet-derived growth factor (PDGF)-BB and recruit PDGF receptor β (PDGFRβ)–overexpressing pericytes, which in turn cover
Kim, Jeong Hun, Chung, Junho, Lee, Seok Jae, Jo, Dong Hyun, Cho, Chang Sik, Chae, Jisu, Kim, Su Ree, Kang, Dongmin, Kim, Soohyun, Yoo, Duck Kyun, Ha, Suji, Suji Ha, Dong Hyun Jo, Chang Sik Cho, Junho Chung, Su Ree Kim, Jisu Chae, Seok Jae Lee, Soohyun Kim, Duck Kyun Yoo, Dongmin Kang, Jeong Hun Kim   +21 more
core   +1 more source

Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model [PDF]

, 2019
Purpose: Pathologic corneal neovascularization is a major cause of blindness worldwide, and treatment options are currently limited. VEGF is one of the critical mediators of corneal neovascularization but current anti-VEGF therapies have produced limited
Law, Samuel M, Diaz-Aguilar, Daniel, Wadehra, Madhuri, Gordon, Lynn K, Sun, Michel M, Chan, Ann M, Duarte, Sergio   +6 more
core   +1 more source

Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin: 1-year results of a randomized clinical trial--VIP report no. 1

, 2001
To determine if photodynamic therapy with verteporfin (Visudyne; CIBA Vision Corp, Duluth, GA) can improve the chance of stabilizing or improving vision (
VipStudy, Group
core   +2 more sources

Sema3f Protects Against Subretinal Neovascularization In Vivo

, 2017
Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti ...
Samuel B. Burnim, Ludwig, Franziska, Reuer, Tristan, Yan Gong, Andreas Stahl, Ye Sun, Schlunck, Günther, Walz, Johanna M., Raffael Liegl, Daniel Böhringer, Burnim, Samuel B., Anima Bühler, Günther Schlunck, Bühler, Anima, Zhang, Peipei, Liu, Chi-Hsiu, Tristan Reuer, Smith, Lois E.H., Liegl, Raffael, Peipei Zhang, Stahl, Andreas, Sun, Ye, Hansjürgen Agostini, Chi-Hsiu Liu, Johanna M. Walz, Lange, Clemens, Steven S. Meng, Clemens Lange, Agostini, Hansjürgen, Böhringer, Daniel, Cakir, Bertan, Meng, Steven S., Gong, Yan, Lois E.H. Smith, Bertan Cakir, Franziska Ludwig   +35 more
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Simulation of corneal neovascularization by inverted diffusion limited aggregation

, 1993
Purpose. The authors modeled the normally avascular mammalian cornea response to injury by neovascularization. The nature of this process remains obscure, although diffusion mechanisms are thought to be involved. Methods.
Landini, G.; id_orcid, Misson, G.
core   +3 more sources

Predictors of pathologic stage in prostatic carcinoma. The role of neovascularity [PDF]

Cancer, 1994
Prostate adenocarcinoma is a significant cause of morbidity and mortality in older men. However, the histologic prevalence far exceeds clinically manifest disease. Increased screening has resulted in the detection of a large number of carcinomas of unknown malignant potential.
M K, Brawer, R E, Deering, M, Brown, S D, Preston, S A, Bigler   +4 more
openaire   +2 more sources

Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies [PDF]

Drug Delivery and Translational Research, 2020
The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration.
Biplab Sarkar, Zain Siddiqui, Ka Kyung Kim, Peter K. Nguyen, Xavier Reyes, Trevor J. McGill, Vivek A. Kumar   +6 more
openaire   +2 more sources