Results 1 to 10 of about 26,418 (118)
ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]
Molecular and Cellular Biology, 2009 Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Victor, Guaiquil +5 more
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Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Ali, Zaheer +24 more
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Interleukin-18 regulates pathological intraocular neovascularization [PDF]
Journal of Leukocyte Biology, 2007 AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Hong, Qiao +10 more
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Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]
Trends in Molecular Medicine, 2018 Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
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Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]
Molecular and Cellular Biology, 2003 ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke, Horiuchi +11 more
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Inhibition of pathologic retinal neovascularization by -defensins
Blood, 2005 Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Matina, Economopoulou +9 more
openaire +3 more sources
Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]
Scientific Reports, 2016 AbstractNetrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser ...
Norbert Kociok +12 more
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Factors associated with the recurrence of choroidal neovascularization in pathologic myopia
Frontiers in Medicine, 2022 PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included. Appearance of ellipsoid zone (EZ) and retinal pigment epithelium (RPE) observed on optical coherence ...
Ruixia Jing +3 more
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Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia
romanian journal of ophthalmology, 2020 Purpose: To evaluate the incidence of choroidal neovascularization (CNV) in high myopic patients who experienced recent visual loss and to describe the characteristics of CNV that develop as a complication of pathologic myopia and were detected by fluorescein angiography (FA).
Tomi, Anca, Ştefan, Irina
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Suppression of pathological ocular neovascularization by a small molecule, SU1498
Biomedicine & Pharmacotherapy, 2020 Selective inhibition of vascular endothelial growth factor receptor (VEGFR), particularly VEGFR-2, is an efficient method for the treatment of ocular neovascularization. SU1498 is a specific inhibitor of VEGFR-2. In this study, we investigated the role of SU1498 in ocular neovascularization.
Tao, Shu-Ya +4 more
openaire +2 more sources