Results 1 to 10 of about 26,246 (203)

Factors associated with the recurrence of choroidal neovascularization in pathologic myopia [PDF]

Frontiers in Medicine, 2022
PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing, Yuxia Bo, Lei Gao, Zhen Wang   +3 more
exaly   +4 more sources

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization [PDF]

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +4 more sources

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
AbstractNetrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser ...
Norbert Kociok, Sergio Crespo‐Garcia, Yong Liang, S. Klein, Christina Nürnberg, Nadine Reichhart, Sergej Skosyrski, Eva Moritz, Anna-Karina B. Maier, William J. Brunken, Olaf Strauß, Manuel Koch, Antonia M. Joussen   +12 more
openalex   +4 more sources

FGF2-induced STAT3 activation regulates pathologic neovascularization

Experimental Eye Research, 2019
Cell-autonomous endothelial cell (EC) fibroblast growth factor receptor (FGFR) signaling through FGFR1/2 is essential for injury-induced wound vascularization and pathologic neovascularization as in blinding eye diseases such as age-related macular degeneration. Which FGF ligand(s) is critical in regulating angiogenesis is unknown.
Tae Jun Lee, David M Ornitz
exaly   +4 more sources

Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]

Molecular and Cellular Biology, 2003
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke Horiuchi, Gisela Weskamp, Lawrence Lum, Hans-Peter Hammes, Hui Cai, Thomas A. Brodie, Thomas Ludwig, Riccardo Chiusaroli, Roland Baron, Klaus T. Preissner, Katia Manova, Carl Blobel   +11 more
openalex   +4 more sources

Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration

Life Science Alliance, 2023
Sult2b1 deficiency attenuates pathologic neovascularization by inhibiting M2 macrophage polarization and promoting cholesterol efflux via the LXR–ABCA1/G1 pathway. Disordered immune responses and cholesterol metabolism have been implicated in age-related
Yafang Wang, Yang Liu, Yan Wang, Yidong Wu, Zhixuan Chen, Feng Wang, Xiaoling Wan, Fenghua Wang, Xiaodong Sun   +8 more
doaj   +3 more sources

Choroidal Changes and Choroidal Neovascularization in Pathological Myopia [PDF]

Güncel Retina Dergisi (Current Retina Journal)
Among the complications of pathological myopia, myopic macular neovascularization (mMNV) is one of the most vision-threatening complications. Despite significant advances in understanding the epidemiology, pathogenesis, and natural history of the disease, there is no standard definition of mMNV.
Semra Koca, Mutluay Bozoklu
openalex   +2 more sources

β-LGND2, an ERβ Selective Agonist, Inhibits Pathologic Retinal Neovascularization [PDF]

Investigative Opthalmology & Visual Science, 2012
The goal of our study was to evaluate the in vitro and in vivo anti-angiogenic effects of ERβ selective agonist, β-LGND2, using human retinal microvascular endothelial cell (HRMVEC) cultures and a mouse model for oxygen-induced retinopathy (OIR).The selectivity of β-LGND2 was determined using binding and transactivation assays.
Anand Giddabasappa, Jeetendra Eswaraka, Christina M. Barrett, Matthew Bauler, Zhongzhi Wu, Muralimohan Yepuru, Duane D. Miller, James T. Dalton   +7 more
openalex   +3 more sources

Inhibition of pathological retinal neovascularization by semaphorin 3A.

Molecular vision, 2013
Pathological retinal angiogenesis is a major cause of vision loss. Semaphorin 3A (Sema3A), a chemorepellent guidance protein, plays crucial roles in neural and vascular patterning. To identify its role in retinal neovascularization, we investigated its antiangiogenic effects.Human umbilical vein endothelial cells (HUVECs) were used for the in vitro ...
Wenzhen Yu, Yujing Bai, Na Han, Fei Wang, Min Zhao, Lvzhen Huang, Xiaoxin Li   +6 more
openalex   +3 more sources

Differences between pathologic and non-pathologic high myopia in 4-year outcomes of anti-VEGF therapy for macular neovascularization

Scientific Reports
This retrospective observational study aimed to investigate the difference in 4-year outcomes of ranibizumab or aflibercept therapy for macular neovascularization (MNV) with high myopia between pathologic myopia (PM) and non-PM.
Manabu Miyata
exaly   +2 more sources