Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]
Scientific Reports, 2016 Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Brunken, William J. +12 more
core +7 more sources
Factors associated with the recurrence of choroidal neovascularization in pathologic myopia
Frontiers in Medicine, 2022 PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing +3 more
doaj +3 more sources
Efficacy of Conbercept in the Treatment of Choroidal Neovascularization Secondary to Pathologic Myopia [PDF]
Frontiers in Medicine, 2021 Purpose: To observe the clinical efficacy of conbercept in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia.Methods: We used retrospective analysis of the clinical data of 20 patients (24 eyes) with pathologic myopia ...
Hui Lu +7 more
doaj +4 more sources
Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization [PDF]
Journal of Biological Chemistry, 2020 Angiogenesis-mediated neovascularization in the eye is usually associated with visual complications. Pathological angiogenesis is particularly prominent in the retina in the settings of proliferative diabetic retinopathy, in which it can lead to permanent loss of vision.
David Gau +8 more
openalex +4 more sources
Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]
Molecular and Cellular Biology, 2003 ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke Horiuchi +11 more
openalex +4 more sources
Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Anthony Mukwaya +25 more
openaire +8 more sources
Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]
Trends in Molecular Medicine, 2018 Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven Swendeman, Timothy Hla
openalex +4 more sources
ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]
Molecular and Cellular Biology, 2009 Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Peter A. Campochiaro +6 more
openaire +3 more sources
Interleukin-18 regulates pathological intraocular neovascularization [PDF]
Journal of Leukocyte Biology, 2007 AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Yasuhiro Ikeda +10 more
openaire +3 more sources
Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy [PDF]
, 2014 Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia,
Chen, Jing +10 more
core +6 more sources