Results 11 to 20 of about 35,226 (335)

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Ophthalmology Science, 2022
Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. Design: Preclinical experimental study.
Santiago Delgado-Tirado, MD, Lucia Gonzalez-Buendia, MD, Miranda An, BA, Dhanesh Amarnani, MS, Daniela Isaacs-Bernal, BSc, Hannah Whitmore, PhD, Said Arevalo-Alquichire, PhD, David Leyton-Cifuentes, BME, Jose M. Ruiz-Moreno, MD, PhD, Joseph F. Arboleda-Velasquez, MD, PhD, Leo A. Kim, MD, PhD   +10 more
doaj   +1 more source

Correlation between the expression of vegf and survival in osteosarcoma [PDF]

Acta Ortopédica Brasileira, 2014
Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall ...
André Mathias Baptista, André Ferrari De França Camargo, Renée Zon Filippi, Cláudia Regina Gomes Cardim Mendes De Oliveira, Raymundo Soares De Azevedo Neto, Olavo Pires De Camargo   +5 more
doaj   +1 more source

Interleukin-18 regulates pathological intraocular neovascularization [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Hong, Qiao, Koh-Hei, Sonoda, Yasuhiro, Ikeda, Takeru, Yoshimura, Kuniaki, Hijioka, Young-Joon, Jo, Yukio, Sassa, Chikako, Tsutsumi-Miyahara, Yasuaki, Hata, Shizuo, Akira, Tatsuro, Ishibashi   +10 more
openaire   +2 more sources

MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A

Frontiers in Pharmacology, 2020
Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan, Xin-Xin Li, De-Wei Peng, Wen-Meng Zhang, Jia Qu, Fan Lu, Fan Lu, Robert J. D’Amato, Robert J. D’Amato, Zai-Long Chi, Zai-Long Chi   +10 more
doaj   +1 more source

Successful Use of Conbercept to Treat Choroidal Neovascularization: A Case Report

Case Reports in Ophthalmology, 2022
Chronic urticaria is a dermatological condition characterized by the appearance of wheals or angioedema longer than 6 weeks. It could cause serious complications such as laryngeal edema, vasculitis, and diarrhea.
Jin Yang, Zheng Liu, Tao Liu
doaj   +1 more source

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy [PDF]

, 2014
Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia,
Chen, Jing, Cui, Zhenghao, Evans, Lucy P., Hatton, Colman J., Hurst, Christian G., Ju, Meihua, Juan, Aimee M., Michan, Shaday, Pei, Dorothy T., Sinclair, David A., Smith, Lois E. H.   +10 more
core   +6 more sources

Evaluation of a novel deep learning based screening system for pathologic myopia [PDF]

International Journal of Ophthalmology, 2023
AIM: To evaluate the clinical application value of the artificial intelligence assisted pathologic myopia (PM-AI) diagnosis model based on deep learning. METHODS: A total of 1156 readable color fundus photographs were collected and annotated based on the
Pei-Fang Ren, Xu-Yuan Tang, Chen-Ying Yu, Li-Li Zhu, Wei-Hua Yang, Ye Shen   +5 more
doaj   +1 more source

ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]

Molecular and Cellular Biology, 2009
Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Victor, Guaiquil, Steven, Swendeman, Tsunehiko, Yoshida, Sai, Chavala, Peter A, Campochiaro, Carl P, Blobel   +5 more
openaire   +2 more sources

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]

Trends in Molecular Medicine, 2018
Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
openaire   +2 more sources

Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3 [PDF]

EBioMedicine, 2021
Pathological neovascularization in neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss in the elderly. Increasing evidence shows that cells of myeloid lineage play important roles in controlling pathological endothelium formation.
Tianxi Wang, Pingzhu Zhou, Xuemei Xie, Yohei Tomita, Steve Cho, Demetrios Tsirukis, Enton Lam, Hongbo Robert Luo, Ye Sun   +8 more
openaire   +4 more sources