Results 11 to 20 of about 35,134 (335)
Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]
Scientific Reports, 2016 Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Brunken, William J. +12 more
core +6 more sources
Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Zaheer Ali +24 more
openalex +9 more sources
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization [PDF]
Cell Reports, 2019 Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz +32 more
doaj +3 more sources
RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization
Journal of Vascular Research, 2023 Objective: The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro. Methods: C57BL/6 was used to establish an OIR model. First, RhoA/ROCK expression was first examined and compared between OIR and healthy controls. Then, we evaluated the effect of Fasudil on
Fen Tang +7 more
openalex +4 more sources
Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia
romanian journal of ophthalmology, 2020 Purpose: To evaluate the incidence of choroidal neovascularization (CNV) in high myopic patients who experienced recent visual loss and to describe the characteristics of CNV that develop as a complication of pathologic myopia and were detected by fluorescein angiography (FA).
Anca Tomi, Irina Ștefan
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Choroidal Changes and Choroidal Neovascularization in Pathological Myopia [PDF]
Güncel Retina Dergisi (Current Retina Journal)Among the complications of pathological myopia, myopic macular neovascularization (mMNV) is one of the most vision-threatening complications. Despite significant advances in understanding the epidemiology, pathogenesis, and natural history of the disease, there is no standard definition of mMNV.
Semra Koca, Mutluay Bozoklu
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Interleukin-18 regulates pathological intraocular neovascularization [PDF]
Journal of Leukocyte Biology, 2007 AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Hong, Qiao +10 more
openaire +2 more sources
ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]
Molecular and Cellular Biology, 2009 Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Victor, Guaiquil +5 more
openaire +2 more sources
Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]
Trends in Molecular Medicine, 2018 Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
openaire +2 more sources
Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3 [PDF]
EBioMedicine, 2021 Pathological neovascularization in neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss in the elderly. Increasing evidence shows that cells of myeloid lineage play important roles in controlling pathological endothelium formation.
Tianxi Wang +8 more
openaire +4 more sources