Results 31 to 40 of about 35,134 (335)

MacrophageSult2b1promotes pathological neovascularization in age-related macular degeneration

Life Science Alliance, 2023
Disordered immune responses and cholesterol metabolism have been implicated in age-related macular degeneration (AMD), the leading cause of blindness in elderly individuals. SULT2B1, the key enzyme of sterol sulfonation, plays important roles in inflammation and cholesterol
Yafang Wang, Liu Yang, Yan Wang, Xiaodong Sun, Zhixuan Chen, Rui Wang, Xiaoling Wan, Fenghua Wang, Xiaodong Sun   +8 more
openaire   +2 more sources

Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]

Molecular and Cellular Biology, 2003
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke, Horiuchi, Gisela, Weskamp, Lawrence, Lum, Hans-Peter, Hammes, Hui, Cai, Thomas A, Brodie, Thomas, Ludwig, Riccardo, Chiusaroli, Roland, Baron, Klaus T, Preissner, Katia, Manova, Carl P, Blobel   +11 more
openaire   +2 more sources

Histological changes secondary to use of anti-angiogenic therapy after interruption of vasa vasorum flow in the descending aorta: results in a porcine model

Jornal Vascular Brasileiro, 2019
Background Anti-angiogenic regulators may have therapeutic implications for onset and progression of atherosclerosis. Objectives To demonstrate histological changes secondary to the use of bevacizumab in the aorta of pigs after interruption of flow in ...
Cyro Castro Júnior, Adamastor Humberto Pereira   +1 more
doaj   +1 more source

Intravitreal conbercept for choroidal neovascularisation secondary to pathological myopia in a real‐world setting in China

BMC Ophthalmology, 2021
Background To evaluate the 12-month efficacy and safety of intravitreal conbercept for myopic choroidal neovascularization (CNV). Methods A retrospective, observational study.
Xin Nie, Yulong Wang, Hong Yi, Yanbin Qiao   +3 more
doaj   +1 more source

Inhibition of pathologic retinal neovascularization by  -defensins

Blood, 2005
Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Matina, Economopoulou, Khalil, Bdeir, Douglas B, Cines, Franz, Fogt, Yasmina, Bdeir, Jacek, Lubkowski, Wuyuan, Lu, Klaus T, Preissner, Hans-Peter, Hammes, Triantafyllos, Chavakis   +9 more
openaire   +3 more sources

Key Multimodal Fundus Imaging Findings to Recognize Multifocal Choroiditis in Patients With Pathological Myopia

Frontiers in Medicine, 2022
Myopia represents a major socioeconomic burden with an increasing prevalence worldwide. Pathologic myopia refers to myopic patients with structural changes in the posterior pole including different patterns of chorioretinal atrophy, choroidal ...
Roberto Gallego-Pinazo, Sara Hernández, Rosa Dolz-Marco   +2 more
doaj   +1 more source

Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features

Patologìâ, 2015
The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate
E. M. Bakurova, R. V. Buzina, R. B. Kondratiuk, Yu. K. Gulkov, I. V. Vasilenko, B. G. Borzenko   +5 more
doaj   +1 more source

Tendinopathy—from basic science to treatment [PDF]

, 2008
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick, AH Drummond, AJ Banes, AN Bamji, AN Corps, AN Corps, AN Corps, AP D'Vaz, B Pasternak, BL Woodley, BM Clancy, CA Speed, D Bjur, EM Badley, G Puddu, G Riley, GAC Murrell, GC Jones, GC Jones, GP Riley, GP Riley, Graham Riley, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Langberg, H Langberg, H Langberg, H Nagase, HA Awad, J Archambault, JA Paoloni, JA Paoloni, JA Paoloni, JD Rompe, JE Carpenter, JL Cook, JM Archambault, L Józsa, L Ohberg, LC Almekinders, LJ McCawley, M Aström, M Benjamin, M Gotoh, M Gotoh, M Lavagnino, M Lavagnino, MD Chard, ME Jones, MH Khan, N Mafi, P Burssens, P Kannus, R Salingcarnboriboon, RA Bank, RF Ker, RK Smith, SA Fenwick, SC Fu, SG Rees, SP Arnoczky, T Pufe, T Pufe, T Samiric, TG Gerich, TW Ehlers, UM Wewer   +69 more
core   +1 more source

Intravitreal anti-VEGF therapy for choroidal neovascularisation secondary to pathological myopia: 4-year outcome [PDF]

, 2013
OBJECTIVE: To report the visual outcome after 4-year follow-up in a series of highly myopic eyes with choroidal neovascularisation (CNV) treated with antivascular endothelial growth factor (anti-VEGF) drugs.
Arias, L, Carneiro, A, Montero, JA, Ruiz-Moreno, JM, Silva, R   +4 more
core   +1 more source

Bevacizumab as a treatment option in gastrointestinal bleeding associated to hereditary hemorrhagic telangiectasia. Case Report

Revista de la Facultad de Medicina, 2019
Introduction: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic disease characterized by the presence of arteriovenous malformations in the nasal mucosa, the tips of fingers, and sometimes in the lungs, the gastrointestinal ...
Erwing Castillo, Jeanette Prada-Arismendy   +1 more
doaj   +1 more source