Prevalence and risk factors for nephrolithiasis in adults with cystic fibrosis: A retrospective cohort study. [PDF]
PLoS ONEBackgroundCalcium oxalate nephrolithiasis is more common in persons living with cystic fibrosis (PwCF) than in the general population. A primary risk factor is exocrine pancreatic insufficiency (EPI) causing enteral hyperoxaluria.
Da Yeon Ryoo +12 more
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Association of nephrolithiasis history with adverse outcomes in cardiovascular–kidney–metabolic syndrome [PDF]
Renal FailureCardiovascular-kidney-metabolic (CKM) syndrome significantly impacts a large segment of the general population. The risk factors associated with progression of CKM syndrome as well as all-cause mortality warrant further investigations.
Xiao Bi +9 more
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Multiomics Mendelian randomization integrating pQTL, eQTL and mQTL data revealed BTN3A2 as a potential drug target for nephrolithiasis [PDF]
Scientific ReportsNephrolithiasis has a high recurrence rate and imposes a heavy burden on patients and society. Therefore, there is an urgent need to explore new effective targets for nephrolithiasis prevention and treatment.
Shanshan Sun +4 more
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Aldehyde Dehydrogenase 2 Gene Polymorphism and Alcohol Consumption Are Associated With Nephrolithiasis in a Chinese Population [PDF]
Molecular Genetics & Genomic MedicineBackground Nephrolithiasis is a common urological disorder and has become a significant global public health issue. Aldehyde dehydrogenase 2 (ALDH2), an important endogenous antioxidant enzyme involved in alcohol metabolism, has been shown to exert ...
Tao Liu +11 more
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Effects of sodium-glucose co-transporter-2 inhibitors on the risk of nephrolithiasis and urinary tract infections in Thai patients with type 2 diabetes: a hospital-based cohort study [PDF]
Diabetology & Metabolic SyndromeBackground Nephrolithiasis is a multifactorial disease with many contributing factors varying across races, ethnicities, and sociocultural backgrounds. Diabetes is a significant independent risk factor for nephrolithiasis.
Thitiya Lukkunaprasit +10 more
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Recenti progressi in medicina, 2000 The development of efficacious techniques for stone elimination, and in particular of extracorporeal lithotripsy, slackened, in the last two decades, the pharmacological research on nephrolithiasis, with the result that the currently available efficacious drugs are very few.
Maalouf NM.
europepmc +3 more sources
Primary Care: Clinics in Office Practice, 2008 Kidney stones affect more than 5% of adults in the United States, and the prevalence is rising. The fundamental cause for all stones is supersaturation of urine with respect to the stone components; factors affecting solubility include urine volume, pH, and total solute excretion.
Elaine M, Worcester, Fredric L, Coe
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Primary Care: Clinics in Office Practice, 2020 Nephrolithiasis, commonly known as kidney stones, may be localized to any part of the urothelial system, causing common systemic symptoms, some of which may become acute. Primary care physicians increasingly are the first line of management for this condition, making recognition and prompt treatment essential.
Kelley, Bishop +2 more
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The -160C>a polymorphism in E-cadherin is associated with the risk of nephrolithiasis. [PDF]
PLoS ONE, 2013 Nephrolithiasis is a common disorder worldwide. E-cadherin (CDH1) is involved in epithelial cell-cell interactions and plays important roles in the etiology of nephrolithiasis.
Mingyue Tan +4 more
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Frontiers in Endocrinology, 2023 BackgroundHyperuricemia and gout are risk factors of nephrolithiasis. However, it is unclear whether the ABCG2 gene contributes to the development of nephrolithiasis.
Ching-Tsai Lin +28 more
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