Results 131 to 140 of about 481,070 (386)

Ursolic Acid Ameliorates Diabetic Nephropathy by Inhibiting JAK2/STAT3-Driven Ferroptosis: Mechanistic Insights from Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy
Yijing Zhou,* Chengli Lou,* Xiuqin Xu, Bo Feng, Xiaoping Fan, Xiangjing Wang Department of Nephropathy, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, People’s Republic of China*These authors contributed equally to this ...
Zhou Y, Lou C, Xu X, Feng B, Fan X, Wang X   +5 more
doaj  

Efficacy and safety of rituximab in patients with PLA2R associated membranous nephropathy and resolved HCV infection

Scientific Reports
Rituximab occasionally induces reactivation of hepatitis C virus (HCV) in patients with resolved HCV infection, sometimes with fatal consequences. As rituximab has become one of the first-line therapies for the treatment of phospholipase A2 receptor ...
Xiaodan Li, Dongxu Song, Yingxuan Hao, Mingjing Ren, Yanhong Guo, Huayan Zhao, Yulin Wang, Lin Tang   +7 more
doaj   +1 more source

METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy

, 2023
Fangfang Wang, Juan Bai, Xin Zhang, Dali Wang, Xin Zhang, Jingwen Xue, Haoyang Chen, Shuxiang Wang, Bao‐Jin Chi, Jing Li, Xiaoru Ma   +10 more
openalex   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Targeting panoptosis: a narrative review of its therapeutic potential in kidney disease

BMC Nephrology
Renal diseases are major global public health challenges due to their complex mechanisms and growing burden. PANoptosis, a unified programmed cell death pathway driven by the PANoptosome complex, involves the combined activation of pyroptotic, apoptotic,
Yuxin Guo, Yanru Zhao, Yanheng Qiao, Yunze Xing, Yaxuan Fang, Yuetong Zhao, Hanqi Yang, Yi Chen, Bo Yang   +8 more
doaj   +1 more source

Microalbuminuria as Predictor of Early Glomerular Injury in Children and Adolescents with Sickle Cell Anaemia at Muhimbili National Hospital Dar es Salaam, Tanzania 2012 [PDF]

, 2012
Microalbuminuria (MA) is the earliest marker of various diseases affecting the renal system. Its relevance in children and adolescents with sickle cell anaemia (SCA), who are known to be prone to renal complications, has not been fully explored in our ...
Christopher, Richard
core  

Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial [PDF]

, 2016
Introduction: Diabetes mellitus affects 9% of the European population and accounts for 15% of healthcare expenditure, in particular, due to excess costs related to complications.
Beige, Joachim, Currie, Gemma, Delles, Christian, Lindhardt, Morten, Mischak, Harald, Navis, Gerjan, Noutsou, Marina, Ortiz, Alberto, Persson, Frederik, Pontillo, Claudia, Rossing, Peter, Ruggenenti, Piero Luigi, Rychlik, Ivan, Spasovski, Goce, von der Leyen, Heiko   +14 more
core   +4 more sources

Oxalate nephropathy

Indian Journal of Nephrology, 2023
Etta, Praveen K., Kota, Mahesh, Guttikonda, Jyothsna, Chakravarthi, Rajasekara, Fathima, Nigar   +4 more
openaire   +2 more sources

DES‐Promoted Synthesis of 3,4‐Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies

Chemistry &Biodiversity, EarlyView.
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar, Sahil Mishra, Pule Seboletswe, Nontobeko Gcabashe, Lalitha Gummidi, Neha Manhas, Talent Makhanya, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +10 more
wiley   +1 more source

Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. [PDF]

, 2016
ObjectiveTo compare different blood pressure (BP) levels in their association with the risk of renal outcomes in type 1 diabetes and to determine whether an intensive glycemic control strategy modifies this association.Research design and methodsWe ...
Gitelman, Stephen E, Grimes, Barbara A, Hsu, Chi-Yuan, Ku, Elaine, Mauer, Michael, McCulloch, Charles E   +5 more
core   +2 more sources