Results 71 to 80 of about 452,381 (401)

Climate change and the kidney [PDF]

, 2019
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality.
Butler-Dawson, Jaime, Diaz, Henry F., Garcia, Gabriela, Hernando, Ana Andres, Johnson, Richard J., Lanaspa, Miguel A., Lemery, Jay, Newman, Lee S., Rodriguez-Iturbe, Bernardo, Roncal-Jimenez, Carlos A., Sato, Yuka, Sánchez-Lozada, Laura G., Tolan, Dean R.   +12 more
core   +1 more source

The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model

Frontiers in Endocrinology, 2022
Increasing evidence suggests that aldosterone (Aldo) plays an essential role in vascular calcification which is a serious threat to cardiovascular disease (CVD) developed from chronic kidney disease (CKD).
Xueying Chang, Jianbing Hao, Xingzhi Wang, Jingwei Liu, Jie Ni, Lirong Hao   +5 more
doaj   +1 more source

M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.

New England Journal of Medicine, 2009
BACKGROUND Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown.
L. Beck, R. Bonegio, G. Lambeau, David M. Beck, D. Powell, Timothy D. Cummins, J. Klein, D. Salant   +7 more
semanticscholar   +1 more source

Urbanization and non-communicable disease mortality in Thailand: an ecological correlation study.

, 2013
This study provides strong evidence from an LMIC that urbanization is associated with mortality from three lifestyle-associated diseases at an ecological level.
Allender, Allender, Archavanitkul, Banwell, Bentham, Boutayeb, Cochrane, Cohen, Faramnuayphol, Flood, Harpham, Hernandez, Holt-Lunstad, Kosulwat, Leon, Lim, Maheswaran, Mathers, Odton, Pattaraarchachai, Petcharoen, Phillips, Porapakkham, Pritchard, Rao, Schorr, Sethapongkul, Sleigh, Smith, Srimahachota, Tangcharoensatien, Vapattanawong, Venketasubramanian, Viravaidya, Vlahov, World Health Organization, Yang, Yiengprungsawan, Yiengprungsawan, Young   +39 more
core   +1 more source

MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy [PDF]

, 2017
Renal fibrosis is a common complication of diabetic nephropathy and is a major cause of end-stage renal disease. Despite the suggested link between renal fibrosis and microRNA (miRNA) dysregulation in diabetic nephropathy, the identification of the ...
Benigni, Ariela, Locatelli, Monica, Macconi, Daniela, Mestdagh, Pieter, Remuzzi, Giuseppe, Rottoli, Daniela, Rudnicki, Michael, Tomasoni, Susanna, Trionfini, Piera, Vandesompele, Jo, Zanchi, Cristina, Zoja, Carlamaria   +11 more
core   +2 more sources

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Association between anemia-related biomarkers and the adequacy of peritoneal dialysis in Chinese patients with chronic kidney disease

Frontiers in Physiology, 2023
Objectives: The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD).Methods: This study included 127 PD patients. The total Kt/V urea (Kt/V)
Jia-Lin Li, Zhen Cai, Jing Zhao, Xiang-Gang Zhu, Qian Li, Yan-Shuang Li, Meng-Chao Liu, Fang-Qiang Cui, Wen-Jing Zhao, Wen-Quan Niu   +9 more
doaj   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway

Molecular Medicine
Background Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-induced renal cell injury.
Yufeng Liu, Mengbi Zhang, Lu Zeng, Yanhong Lai, Songzhao Wu, Xiaoyan Su   +5 more
doaj   +1 more source