Results 1 to 10 of about 121,280 (344)

Cisplatin Nephrotoxicity

American Journal of Kidney Diseases, 1986
Cis-dichlorodiammine platinum (II), or cisplatin, has emerged as a principal chemotherapeutic agent in the treatment of otherwise resistant solid tumors and is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its nephrotoxicity, which has made it necessary both to lower its dosage and
R, Safirstein, J, Winston, M, Goldstein, D, Moel, S, Dikman, J, Guttenplan   +5 more
openaire   +2 more sources

Genome-Wide Analyses of Nephrotoxicity in Platinum-Treated Cancer Patients Identify Association with Genetic Variant in RBMS3 and Acute Kidney Injury [PDF]

, 2022
Marije J. Klumpers, Ward De Witte, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Corrie Gidding, Sita H. Vermeulen, C.M.L. Driessen, Carla M. van Herpen, Esther van Meerten, Henk‐Jan Guchelaar, Marieke J. H. Coenen, D. Maroeska W. M. te Loo   +13 more
openalex   +1 more source

Precision nephrotoxicity testing using 3D in vitro models

Cell & Bioscience, 2023
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of ...
Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang   +16 more
doaj   +1 more source

Factors Affecting the Colistin Nephrotoxicity: Advanced Age and/or Other Factors?

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2022
Introduction: The population is aging, and older adults comprise most patients in the intensive care units. Colistin (COL) has been re-introduced to treat increasingly common resistant Gram-negative bacterial infections. Our study aims to investigate the
Tuğba ARSLAN GÜLEN, Ayfer İMRE, Üner KAYABAŞ   +2 more
doaj   +1 more source

Comparative study on hemato- and nephrotoxicity profile of weekly versus every 3-weekly cisplatin dosage during induction chemotherapy in locally advanced head neck squamous cell carcinoma [PDF]

, 2021
Adity Chakraborty, Abhinandan Bhattacharjee, Amlan Nath, Shibashis Deb, Aakanksha Rathor   +4 more
openalex   +1 more source

Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population

Translational Oncology
Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated ...
Cong Wang, Guifei Deng, Siyu Niu, Xianglong Meng   +3 more
doaj   +1 more source

Vancomycin dosing design method considering risk factors for nephrotoxicity

Journal of Pharmaceutical Health Care and Sciences
Background Vancomycin (VCM) induces nephrotoxicity in a dose-dependent manner, and patients with risk factors for nephrotoxicity have been reported to develop nephrotoxicity even within the effective concentration range.
Yoshihiko Matsuki, Yutaro Kozima, Megumi Yanagi, Ken-ichi Sako, Tamaki Watanabe, Nobuhiro Yasuno, Shigekazu Watanabe   +6 more
doaj   +1 more source

Can Spesific Biomarkers Be Used to Enlighten the Major Mechanisms of Acute High Dose Diclofenac Sodium-Related Nephrotoxicity?

Eurasian Journal of Emergency Medicine, 2022
Aim:The aim of this study was to examine the basic mechanisms that play a role in the acute nephrotoxicity caused by diclofenac sodium.Materials and Methods:Only water was given to the control group; however, the diclofenac sodium group was group ...
Sinem Doğruyol, İlker Akbaş, Abdullah Osman Koçak, Serpil Aygörmez, Habip Emrah Leylek, Sultan Tuna Akgöl Gür, Özge Ertener   +6 more
doaj   +1 more source

Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection. [PDF]

PLoS ONE, 2014
Nephrotoxicity remains a problem for patients who receive cisplatin chemotherapy. We retrospectively evaluated potential risk factors for cisplatin-induced nephrotoxicity as well as the potential impact of intravenous magnesium supplementation on such ...
Yasuhiro Kidera, Hisato Kawakami, Tsutomu Sakiyama, Kunio Okamoto, Kaoru Tanaka, Masayuki Takeda, Hiroyasu Kaneda, Shin-ichi Nishina, Junji Tsurutani, Kimiko Fujiwara, Morihiro Nomura, Yuzuru Yamazoe, Yasutaka Chiba, Shozo Nishida, Takao Tamura, Kazuhiko Nakagawa   +15 more
doaj   +1 more source

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

Frontiers in Pharmacology, 2018
Background: Nephrotoxicity is a notable adverse effect in cisplatin treated patients characterized by tubular injury and/or increased serum creatinine (SCr) with incidence varying from 20 to 70%.
Zulfan Zazuli, Zulfan Zazuli, Susanne Vijverberg, Elise Slob, Geoffrey Liu, Geoffrey Liu, Bruce Carleton, Bruce Carleton, Bruce Carleton, Joris Veltman, Paul Baas, Paul Baas, Rosalinde Masereeuw, Anke-Hilse Maitland-van der Zee   +13 more
doaj   +1 more source