Results 1 to 10 of about 111,114 (198)
Journal of Advanced Pharmaceutical Technology & Research, 2019 Nephrotoxicity is defining as rapid deterioration in the kidney function due to toxic effect of medications and chemicals. There are various forms, and some drugs may affect renal function in more than one way.
Marwa S Al-Naimi +4 more
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Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population [PDF]
Translational OncologyIntroduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated ...
Cong Wang +3 more
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Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Tacrolimus has been used as an immunosuppressive agent in organ transplantation. Despite the therapeutic benefits, tacrolimus’s use is limited due to its nephrotoxicity.
Jin Won Kim +12 more
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Natural products: potential treatments for cisplatin-induced nephrotoxicity
Acta Pharmacologica Sinica, 2021 Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc.
Chunyan Fang +7 more
semanticscholar +1 more source
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
Cell Death and Disease, 2021 Chemotherapy drug-induced nephrotoxicity limits clinical applications for treating cancers. Pyroptosis, a newly discovered programmed cell death, was recently reported to be associated with kidney diseases.
Xiujin Shen +4 more
semanticscholar +1 more source
The Mechanism of Drug Nephrotoxicity and the Methods for Preventing Kidney Damage
International Journal of Molecular Sciences, 2021 Acute kidney injury (AKI) is a global health challenge of vast proportions, as approx. 13.3% of people worldwide are affected annually. The pathophysiology of AKI is very complex, but its main causes are sepsis, ischemia, and nephrotoxicity ...
E. Kwiatkowska +5 more
semanticscholar +1 more source
Sex Difference in Cisplatin-Induced Nephrotoxicity: Laboratory and Clinical Findings
Journal of Toxicology, 2022 Cisplatin (CP) as the most important anticancer drug has limited usage due to a lot of side effects such as nephrotoxicity. Additionally, nephrotoxicity is gender/sex-related.
Fatemeh Eshraghi-Jazi, Mehdi Nematbakhsh
doaj +1 more source
Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
International Journal of Nephrology, 2022 Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of ...
Muluken Altaye Ayza +6 more
semanticscholar +1 more source
Asian Pacific Journal of Cancer Biology, 2022 Introduction: Head and neck cancers are the common cancers in developing countries, especially in Southeast Asia. Concurrent chemoradiation is the treatment of choice for locally advanced stage III to IVB squamous cell carcinoma of head and neck ...
Mahfujul Ahmed Riad
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In Silico Prediction and Insights Into the Structural Basis of Drug Induced Nephrotoxicity
Frontiers in Pharmacology, 2022 Drug induced nephrotoxicity is a major clinical challenge, and it is always associated with higher costs for the pharmaceutical industry and due to detection during the late stages of drug development.
Yinping Shi +4 more
semanticscholar +1 more source