Results 151 to 160 of about 63,588 (218)

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Dioscin Promotes Ferroptosis in Cervical Cancer Cells via the TIGAR‐ROS Axis

Cancer Science, EarlyView.
Dioscin suppresses cervical cancer progression by promoting ferroptosis. Mechanistically, Dioscin binds to TIGAR and inhibits TIGAR function, elevating ROS levels and inducing ferroptosis. ABSTRACT Cervical cancer seriously threatens women's life and health, highlighting the urgent need for targeted therapies.
Yameng Liu, Hongli Xi, Shaoju Min, Hanlin Yang, Li Hou, Hailong Zhang, Yujie Tan   +6 more
wiley   +1 more source

Anaesthetic management of a horse with acute kidney injury

Equine Veterinary Education, EarlyView.
Summary Anaesthetic management of animals with acute kidney injuries (AKI) is complex and poses considerable risk. There are no publications describing management of anaesthetised horses with AKI. Perioperative and anaesthetic care of a Thoroughbred filly presented with traumatic injuries and subsequent AKI is described.
C. T. Quinn, K. J. Hughes, A. N. Walton
wiley   +1 more source

Amelioration of Cisplatin Nephrotoxicity by Fe-Pt Coordination Exchange-Triggered Ferroptosis Suppression. [PDF]

Adv Healthc Mater
Chen T, Du P, Liu Y, Chen X, Wang Z, Li X, Zhao X, Zhao Y.   +7 more
europepmc   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Complexed rifampicin with iron mitigates doxorubicin-induced nephrotoxicity. [PDF]

BMC Pharmacol Toxicol
Basal OA, Saad EA, El Sadda RR.
europepmc   +1 more source

HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise

HIV Medicine, EarlyView.
Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil, Nicola Wearne, Brendon Price, Frank Post, Dami A. Collier   +4 more
wiley   +1 more source

The outcomes in nephrotoxicity among therapies utilizing three distinct polymyxins: a systematic review and network meta-analysis. [PDF]

Front Med (Lausanne)
Zhang H, Chen H, Zhang Z, Shi H, Li J, Zhang X, Wang S, Liao X.   +7 more
europepmc   +1 more source