Results 141 to 150 of about 72,055 (308)

Development of Preclinical Models of Vancomycin Nephrotoxicity [PDF]

Background: Vancomycin is one of the most frequently used antibiotics to treat infections caused by gram-positive bacteria. However, its clinical use is hindered by nephrotoxicity. To facilitate optimal vancomycin use in the clinic, the objective of this
Vuong, Linh T.
core  

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Review of Aminoglycoside Trough Concentrations in Relationship with Nephrotoxicity [PDF]

, 2015
Introduction: Aminoglycosides are antibiotics primarily used in the treatment of infections caused by gram-negative bacteria. The most significant adverse effect observed in aminoglycosides is nephrotoxicity.
Wickersham, Alisha, Ucchino, Hannah
core  

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross‐Sectional Analysis on Cement Plant Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Heavy metal exposure is known to have various effects on renal function and blood glucose regulation. The main objective of this study was to evaluate the effects of cement dust and some metal (cadmium, manganese, nickel, and zinc) exposure on blood glucose and renal function parameters in male cement plant workers.
Duygu Seyhan Erdoğan, Fatma Bozdag, Fatıma Betül Topcu, Osman Burak Demirbas, Sultan Pinar Cetintepe, Mustafa Necmi Ilhan   +5 more
wiley   +1 more source

Exploring the Chemical Complexity and Toxicological Behaviour of Semi‐permanent Make‐Up Pigments: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Semi‐permanent make‐up (SPMU), or micropigmentation, involves implanting pigments into the dermal layer of the skin for cosmetic enhancement. Unlike topical cosmetics, which are rapidly cleared from the body, SPMU pigments persist in living tissues, raising unique toxicological considerations.
T. A. N. Kaye, M. B. Komane, A. P. Manyisane, R. Manganyi   +3 more
wiley   +1 more source

Revisiting Burn Wound Infections: A Comprehensive Review on the Dual Potential of Phages and Probiotics Against Acinetobacter baumannii

Journal of Clinical Laboratory Analysis, EarlyView.
Effect Probiotics on immune system modulation and wound Healing. ABSTRACT Introduction Burn wound infections caused by Acinetobacter baumannii remain a critical clinical challenge due to its extensive multidrug resistance, particularly against carbapenems.
Zeinab Fagheei Aghmiyuni, Shahrzad Aliniay Sharafshadehi, Roghayeh Afifirad, Elnaz Bafandeh, Maryam Mokhtaryan, Roya Ghanavati, Atieh Darbandi   +6 more
wiley   +1 more source

Nephrotoxicity of New Antibiotics: A Systematic Review [PDF]

Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Laura T. Romanos, Matthew E. Falagas, Charalampos Loutradis, Panagiotis Stathopoulos   +3 more
core   +1 more source

A Study on Predicting Split Renal Function Using Renal Blood Flow Weighted Estimated Glomerular Filtration Rate From Arterial Spin Labeling MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Traditional methods for evaluating split renal function, including contrast‐enhanced CT and radionuclide imaging, have limitations related to ionizing radiation or potentially nephrotoxic contrast agents. Purpose To investigate the value of renal blood flow (RBF)‐weighted estimated glomerular filtration rate (eGFR) derived from ...
Zhiyong Lin, Yuxi Li, Rui Wang, Wei Li, Jinxia Zhu, Bernd Kuehn, Jianxing Qiu, Jianping Li   +7 more
wiley   +1 more source

The impacts of energy and protein provision on anthropometric changes in infants with critical congenital heart disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Malnutrition in patients with critical congenital heart disease (CCHD) is associated with worse outcomes, however, feeding challenges, and changes in metabolic demands obscure the relationship between nutrient intake and growth in this patient population.
Colin R. Tang‐Whitmore, Cydney Coleman, Brittany Faanes, Laura Gearman, Brian F. Joy, Stacie Knutson, Benjamin W. Langworthy, Katie M. Pfister, Catherine Larson‐Nath   +8 more
wiley   +1 more source