Results 271 to 280 of about 107,851 (315)
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Toxicologic Pathology, 1986
Aminoglycosides are life-saving antibiotics in patients with gram negative sepsis. Renal dysfunction occurs in approximately 10% of all clinical courses of aminoglycosides. Because of close pharmacokinetic and toxicologic similarities, rats are excellent human surrogates for comparing the nephrotoxic potentials of these antibiotics. Comparisons in rats
G H, Hottendorf, P D, Williams
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Aminoglycosides are life-saving antibiotics in patients with gram negative sepsis. Renal dysfunction occurs in approximately 10% of all clinical courses of aminoglycosides. Because of close pharmacokinetic and toxicologic similarities, rats are excellent human surrogates for comparing the nephrotoxic potentials of these antibiotics. Comparisons in rats
G H, Hottendorf, P D, Williams
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Drug Intelligence & Clinical Pharmacy, 1982
Lithium-induced nephrotoxicity was first predicted in laboratory animals more than 30 years ago. Evidence in humans, however, did not begin to accumulate until the 1970s. By 1977, anecdotal information was available to suggest that lithium intoxication was not necessarily a prerequisite for the development of nephrotoxicity and that renal damage also ...
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Lithium-induced nephrotoxicity was first predicted in laboratory animals more than 30 years ago. Evidence in humans, however, did not begin to accumulate until the 1970s. By 1977, anecdotal information was available to suggest that lithium intoxication was not necessarily a prerequisite for the development of nephrotoxicity and that renal damage also ...
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The American Journal of Medicine, 1978
Platinum coordination complexes have recently been introduced in cancer chemotherapy with considerable success. However, significant nephrotoxicity has emerged as a factor that limits the therapeutic usefulness of these compounds. In this article we review the available knowledge on platinum nephrotoxicity and its prevention that has been derived from ...
N E, Madias, J T, Harrington
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Platinum coordination complexes have recently been introduced in cancer chemotherapy with considerable success. However, significant nephrotoxicity has emerged as a factor that limits the therapeutic usefulness of these compounds. In this article we review the available knowledge on platinum nephrotoxicity and its prevention that has been derived from ...
N E, Madias, J T, Harrington
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Nephrotoxicity of nitrosoureas
Cancer, 1981Irreversible and progressive renal parenchymal damage and functional impairment occurred in the majority of patients receiving at least six courses (200 mg/m2 of BCNU and/or methyl CCNU at eight-week intervals) of nitrosoureas for therapy of malignant brain tumors.
R G, Schacht +4 more
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Antiretroviral Nephrotoxicities
Seminars in Nephrology, 2008With the introduction of combination antiretroviral therapy, there have been substantial declines in both morbidity and mortality associated with human immunodeficiency virus (HIV)-1 infection. However, data increasingly indicate that HIV-1-infected individuals are faced with accelerated rates of chronic diseases that afflict the general population ...
Mohamed G, Atta +2 more
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The American Journal of Medicine, 1990
The high incidence of associated nephrotoxicity represents an important concern in the use of aminoglycoside antibiotics, which have been implicated as one of the primary causes of drug-induced acute renal failure. Several factors, including the underlying health of the patient, criteria used to define nephrotoxicity, and the specific aminoglycoside ...
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The high incidence of associated nephrotoxicity represents an important concern in the use of aminoglycoside antibiotics, which have been implicated as one of the primary causes of drug-induced acute renal failure. Several factors, including the underlying health of the patient, criteria used to define nephrotoxicity, and the specific aminoglycoside ...
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Glycopeptides and nephrotoxicity
Intensive Care Medicine, 1994Infections due to Gram-positive bacteria have become an increasing problem in the ICU. Furthermore, multidrug resistance among Gram-positive pathogens is increasingly recognized. Empirical therapy with antibiotic regimens that are effective against Gram-positive pathogens is often required in the ICU.
A W, Chow, R M, Azar
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Pediatric Nephrology, 1988
The nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics and indomethacin are reviewed. These drugs were chosen because they are among the most frequent causes of renal injury in children. In addition, their nephrotoxicity is caused by different mechanisms.
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The nephrotoxic effects of cyclosporine, aminoglycoside antibiotics, cisplatin, amphotericin B, beta-lactam antibiotics and indomethacin are reviewed. These drugs were chosen because they are among the most frequent causes of renal injury in children. In addition, their nephrotoxicity is caused by different mechanisms.
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JAMA: The Journal of the American Medical Association, 1967
The potentially nephrotoxic antibiotics in current clinical use are neomycin, kanamycin, paromomycin, bacitracin, the polymyxins (polymyxin B, and colistin), and amphotericin B. 1-3 Nephrotoxicity was reported with early lots of streptomycin, but the drug now commercially available does not appear to have this property.
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The potentially nephrotoxic antibiotics in current clinical use are neomycin, kanamycin, paromomycin, bacitracin, the polymyxins (polymyxin B, and colistin), and amphotericin B. 1-3 Nephrotoxicity was reported with early lots of streptomycin, but the drug now commercially available does not appear to have this property.
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NEPHROTOXICITY OF CYCLOSPORIN A
The Lancet, 1981J M, Hows, E C, Gordon-Smith
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