Results 51 to 60 of about 111,114 (198)

Nephroprotective Effects of Alhagi camelorum against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats

Molecules, 2022
Alhagi camelorum (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m2) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression ...
Muhammad Omer Iqbal, Muhammad Masood Ahmed, Shafia Arshad, Usman Javaid, Imran Ahmad Khan, Majid Manzoor, Shumaila Andleeb, Romana Riaz, Shaukat Hussain Munawar, Zahid Manzoor, Asma Mumtaz   +10 more
doaj   +1 more source

Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis [PDF]

, 2022
Yoshitaka Saito, Tatsuhiko Sakamoto, Yoh Takekuma, Masaki Kobayashi, Keisuke Okamoto, Naofumi Shinagawa, Yasushi Shimizu, Ichiro Kinoshita, Mitsuru Sugawara   +8 more
openalex   +1 more source

Comparison of preventive effects of combined furosemide and mannitol versus single diuretics, furosemide or mannitol, on cisplatin-induced nephrotoxicity

Scientific Reports
Cisplatin (CDDP)-induced nephrotoxicity is a common dose-limiting toxicity, and diuretics are often administered to prevent nephrotoxicity. However, the efficacy and optimal administration of diuretics in preventing CDDP-induced nephrotoxicity remain to ...
Ayaka Takagi, Takanori Miyoshi, Toshinobu Hayashi, Hinako Koizumi, Kyouichi Tsumagari, Chiaki Yokota, Takafumi Nakano, Koichi Matsuo, Takashi Egawa   +8 more
doaj   +1 more source

Nephrotoxicity of Herbal Medicine and Its Prevention

Frontiers in Pharmacology, 2020
Herbal medicine (HM) has been widely used to treat diseases for thousands of years and has greatly contributed to the health of human beings. Many new drugs have been developed from HM, such as artemisinin.
Xiaofen Xu, Ruyi Zhu, Jialiang Ying, Mengting Zhao, Xin Wu, Gang Cao, Kuilong Wang   +6 more
semanticscholar   +1 more source

Precision nephrotoxicity testing using 3D in vitro models

Cell & Bioscience, 2023
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of ...
Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang   +16 more
doaj   +1 more source

Factors Affecting the Colistin Nephrotoxicity: Advanced Age and/or Other Factors?

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2022
Introduction: The population is aging, and older adults comprise most patients in the intensive care units. Colistin (COL) has been re-introduced to treat increasingly common resistant Gram-negative bacterial infections. Our study aims to investigate the
Tuğba ARSLAN GÜLEN, Ayfer İMRE, Üner KAYABAŞ   +2 more
doaj   +1 more source

Mechanisms of Cisplatin Nephrotoxicity

Toxins, 2010
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin ...
Ronald P. Miller, R. Tadagavadi, G. Ramesh, W. B. Reeves   +3 more
semanticscholar   +1 more source

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

Cell Death and Disease, 2018
Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells.
Ying Wang, Chengyuan Tang, Juan Cai, Guochun Chen, Dongshan Zhang, Zhuohua Zhang, Z. Dong   +6 more
semanticscholar   +1 more source

Vancomycin dosing design method considering risk factors for nephrotoxicity

Journal of Pharmaceutical Health Care and Sciences
Background Vancomycin (VCM) induces nephrotoxicity in a dose-dependent manner, and patients with risk factors for nephrotoxicity have been reported to develop nephrotoxicity even within the effective concentration range.
Yoshihiko Matsuki, Yutaro Kozima, Megumi Yanagi, Ken-ichi Sako, Tamaki Watanabe, Nobuhiro Yasuno, Shigekazu Watanabe   +6 more
doaj   +1 more source

Can Spesific Biomarkers Be Used to Enlighten the Major Mechanisms of Acute High Dose Diclofenac Sodium-Related Nephrotoxicity?

Eurasian Journal of Emergency Medicine, 2022
Aim:The aim of this study was to examine the basic mechanisms that play a role in the acute nephrotoxicity caused by diclofenac sodium.Materials and Methods:Only water was given to the control group; however, the diclofenac sodium group was group ...
Sinem Doğruyol, İlker Akbaş, Abdullah Osman Koçak, Serpil Aygörmez, Habip Emrah Leylek, Sultan Tuna Akgöl Gür, Özge Ertener   +6 more
doaj   +1 more source