Results 61 to 70 of about 78,162 (300)

Effectiveness and Nephrotoxicity of Intravenous Polymyxin B in Chinese Patients With MDR and XDR Nosocomial Pneumonia

Frontiers in Pharmacology, 2021
Background: Nosocomial pneumonia is a major health and economic burden globally. Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Gram-negative bacteria are the most common causative pathogens in critically-ill patients.
Huihui Zeng, Huihui Zeng, Huihui Zeng, Zihang Zeng, Zihang Zeng, Zihang Zeng, Xianglong Kong, Hongliang Zhang, Ping Chen, Ping Chen, Ping Chen, Hong Luo, Hong Luo, Hong Luo, Yan Chen, Yan Chen, Yan Chen   +16 more
doaj   +1 more source

The development of a cellular model of nephrosis to evaluate nephrotoxic biomarkers [PDF]

, 2005
Nephrotoxicity is one of the major causes for compound failure late in the drug development process. Pharmaceutical companies are interested in identifying biomarkers of nephrotoxicity which can be used to identify potential toxic compounds earlier in ...
Marlow, Gareth
core  

Tenofovir Nephrotoxicity: 2011 Update [PDF]

, 2011
Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus.
Parra-Rodríguez, Alejandro, Alejandro Parra-Rodriguez, Rafael Selgas, Ruiz Ortega, Marta, Marta Ruiz-Ortega, Fernández Fernández, Beatriz, Selgas, Rafael, Izquierdo, María C., Beatriz Fernandez-Fernandez, Poveda, Jonay, Montoya-Ferrer, Ana, Sainz-Prestel, Valeria, Egido de los Ríos, Jesús, Jonay Poveda, Natalia Ortiz-Martin, Ortíz-Martín, Natalia, Jesus Egido, Maria C. Izquierdo, Maria D. Sanchez-Niño, Sánchez Niño, María Dolores, Valeria Sainz-Prestel, Ana B. Sanz, Alberto Ortiz, Sanz Bartolomé, Ana Belén, Ortiz Arduán, Alberto, Ana Montoya-Ferrer   +25 more
core   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Comparison of preventive effects of combined furosemide and mannitol versus single diuretics, furosemide or mannitol, on cisplatin-induced nephrotoxicity

Scientific Reports
Cisplatin (CDDP)-induced nephrotoxicity is a common dose-limiting toxicity, and diuretics are often administered to prevent nephrotoxicity. However, the efficacy and optimal administration of diuretics in preventing CDDP-induced nephrotoxicity remain to ...
Ayaka Takagi, Takanori Miyoshi, Toshinobu Hayashi, Hinako Koizumi, Kyouichi Tsumagari, Chiaki Yokota, Takafumi Nakano, Koichi Matsuo, Takashi Egawa   +8 more
doaj   +1 more source

Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia

Frontiers in Nephrology
IntroductionAntiretroviral therapy (ART) increases the life expectancy of persons living with HIV (PLWH), but not without potentially serious adverse effects.
Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu   +15 more
doaj   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Aminoglycoside and Nephrotoxicity

Kidney and Blood Pressure Research, 1987
The effect of three aminoglycosides – gentamicin, netilmicin and amikacin – on renal acid excretion was studied in male rats treated with doses equivalent to those clinically used. The amikacin and netilmicin groups showed no important changes in the values of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and U/P inulin ratio ...
V L, Silva, F Z, Gil, G, Nascimento, M F, Cavanal   +3 more
openaire   +2 more sources

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

The nephrotoxicity of analgesics

Journal of Pharmacy and Pharmacology, 1966
AbstractIN recent years there has been increasing suspicion that prolonged or excessive use of analgesics may result in progressive renal damage very similar to that produced by chronic pyelonephritis. Phenacetin (acetophenetidin) has been widely incriminated as the offending drug, mainly because it was common to all the analgesic mixtures mentioned in
openaire   +2 more sources