Results 51 to 60 of about 78,162 (300)

Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease

Renal Failure
Background Calcineurin inhibitors (CNIs), such as cyclosporine (CsA) and tacrolimus (TAC), are commonly used to treat children with complicated minimal change nephrotic syndrome.
Bei Jin, Ziji Lu, Cheng Cheng, Yuxin Pei, Lizhi Chen, Zhihui Yue, Aihua Lin, Shicong Yang, Ying Mo, Xiaoyun Jiang   +9 more
doaj   +1 more source

Comparison of nephrotoxicity of Colistin with Polymyxin B administered in currently recommended doses: a prospective study

Annals of Clinical Microbiology and Antimicrobials, 2018
Background The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations.
Ritesh Aggarwal, Arun Dewan
doaj   +1 more source

Atazanavir nephrotoxicity [PDF]

Clinical Kidney Journal, 2015
Atazanavir is commonly used as one of the key drugs in combination antiretroviral therapy for human immunodeficiency virus (HIV). However, atazanavir has the potential to yield its crystalline precipitation in urine and renal interstitial tissues, leading to crystalluria, urolithiasis, acute kidney injury (AKI) or chronic kidney disease (CKD).
Hara, Masaki, Suganuma, Akihiko, Yanagisawa, Naoki, Imamura, Akifumi, Hishima, Tsunekazu, Ando, Minoru   +5 more
openaire   +2 more sources

Tacrolimus-induced nephrotoxicity and genetic variability:A review [PDF]

, 2012
Background: Calcineurin inhibition (CNI) is the mainstay of immunosuppressant therapy for most solid organ transplant patients. High tacrolimus levels are related with acute nephrotoxicity, but the relationship with chronic toxicity is less clear ...
Koren, Gideon, Dubé, Marie Pierre, Madadi, Parvaz, Hesselink, Dennis A.; id_orcid, Gijsen, Violette M.G.J., de Wildt, Saskia N.   +5 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity [PDF]

, 2017
Colistin therapy is used as the last line of defense against life-threatening Gram-negative infections. Nephrotoxicity is the major dose-limiting side effect that impedes optimal dosing of patients.
Maizbha U. Ahmed, Jiayuan Huang, Jiping Wang, Jian Li, Elena K. Schneider, Mohammad A. K. Azad, Roger L. Nation, Sivashangarie S. Sivanesan, Tony Velkov   +8 more
core   +2 more sources

Cisplatin Nephrotoxicity and Sexual Dimorphism: Experimental Trials for Protection [PDF]

Zagazig University Medical Journal
Background: Cisplatin is one of the most commonly used anticancer agents either alone or in combination. Nephrotoxicity is the most common and distressing side effect of its usage.
Rania Soliman, Manal El-Meligy, Nouran Deebis, Maha Abdul Rahman   +3 more
doaj   +1 more source

Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and vomiting (CINV).
Miho Takemura, Kenji Ikemura, Masayoshi Kondo, Fumihiro Yamane, Mikiko Ueda, Masahiro Okuda   +5 more
doaj   +1 more source