Results 1 to 10 of about 26,327 (353)

Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
M.A.S. Medeiros, M.S.F. França, G. Boileau, L. Juliano, K.M. Carvalho   +4 more
doaj   +7 more sources

Active site mutations change the cleavage specificity of neprilysin. [PDF]

PLoS ONE, 2012
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton, Lisa J Hitchcook, David W Rodgers, Luke H Bradley, Louis B Hersh   +4 more
doaj   +3 more sources

Relevance of Neutrophil Neprilysin in Heart Failure [PDF]

Cells, 2021
Significant expression of neprilysin (NEP) is found on neutrophils, which present the transmembrane integer form of the enzyme. This study aimed to investigate the relationship of neutrophil transmembrane neprilysin (mNEP) with disease severity, adverse ...
Suriya Prausmüller, Georg Spinka, Henrike Arfsten, Stefanie Stasek, Rene Rettl, Philipp Emanuel Bartko, Georg Goliasch, Guido Strunk, Julia Riebandt, Julia Mascherbauer, Diana Bonderman, Christian Hengstenberg, Martin Hülsmann, Noemi Pavo   +13 more
doaj   +3 more sources

Neprilysin Inhibitors and Bradykinin [PDF]

Frontiers in Medicine, 2018
Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury.
Duncan J. Campbell, Duncan J. Campbell, Duncan J. Campbell   +2 more
doaj   +5 more sources

IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts [PDF]

International Journal of General Medicine
ChengLing Fan,1,2 HongXia Zhou,2 YuFei Pan,3 Dan Lu1 1Medical College, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Baoying Maternal and Child Health Hospital, Yangzhou, Jiangsu ...
Fan C, Zhou H, Pan Y, Lu D
doaj   +2 more sources

Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. [PDF]

, 2014
Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness.
Brunel, P, Cardenas, P, Cockcroft, JR, Hester, A, Kario, K, Williams, B, Zappe, DH, Zhang, J   +7 more
core   +3 more sources

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. [PDF]

, 2014
The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin ...
A Bernard, A Karagiannis, A Savoye, A Urban, B Rudy, BW Okaty, CL Thompson, CN Brocker, CN Pfeffer, D Wang, DA Lewis, Ed S Lein, ES Lein, G Fattorini, GA Ascoli, GW Huntley, H Taniguchi, J Helm, J Rossier, J-H Cabungcal, JA Cardin, JF Zander, JH Cabungcal, JH Cabungcal, JR Glausier, K Do, KA Giamanco, L Verret, M Cuénod, M Hawrylycz, M Schönlau, MR Celio, N Iwata, NN Nalivaeva, Q Perrenoud, Q Perrenoud, RY Tsien, S Berretta, S Rivera, SA Mauney, T Gallopin, T Pizzorusso, V Nagy, VS Sohal   +43 more
core   +4 more sources

Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. [PDF]

microPublication biology, 2021
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases.
Meyer, Heiko, Buhr, Annika, Callaerts, Patrick, Schiemann, Ronja, Wolfner, Mariana F., Marygold, Steven J.   +5 more
openaire   +3 more sources

Substance P and Neprilysin in Chronic Pancreatitis [PDF]

European Surgical Research, 2012
<b><i>Background/Aims:</i></b> We aimed to analyze substance P (SP) and neprilysin (NEP), the membrane metallopeptidase that degrades SP, in chronic pancreatitis (CP). <b><i>Methods:</i></b> SP and NEP mRNA levels were analyzed by qRT-PCR in tissue samples from 30 patients with CP and 8 organ donors.
Giuseppe Mascetta, Fabio F. di Mola, Francesca Tavano, Federico Selvaggi, N. Giese, Claudio Bassi, M.W. Büchler, Helmut Frieß, Pierluigi Di Sebastiano   +8 more
openalex   +6 more sources

The immuneregulator role of neprilysin (NEP) in invertebrates [PDF]

Invertebrate Survival Journal, 2012
Neprilysin (NEP) represents an important enzyme in both vertebrates and invertebrates. In the present report we have focused our attention to invertebrates. In particular, a structure related to CD10/NEP as well as its activity in different tissues, such
A. Grimaldi, D. Malagoli, E. Ottaviani, M. de Eguileor   +3 more
core   +5 more sources