Results 1 to 10 of about 14,072 (184)
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. [PDF]
microPublication biology, 2021 The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space.
Buhr, Annika +5 more
core +5 more sources
Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure [PDF]
JACC. Heart failure, 2018 Objectives: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction.
Claggett, Brian +14 more
core +13 more sources
Relevance of Neutrophil Neprilysin in Heart Failure [PDF]
Cells, 2021 Significant expression of neprilysin (NEP) is found on neutrophils, which present the transmembrane integer form of the enzyme. This study aimed to investigate the relationship of neutrophil transmembrane neprilysin (mNEP) with disease severity, adverse ...
Suriya Prausmüller +13 more
doaj +3 more sources
Journal of Diabetes, 2023 AbstractNeprilysin (NEP) is a transmembrane zinc‐dependent metalloproteinase that inactivates various peptide hormones including glucagon‐like peptide 1 (GLP‐1). NEP inhibitors may be effective in the management of type 2 diabetes mellitus (T2DM) by increasing the circulating level of GLP‐1.
Faisal Holil AlAnazi +8 more
openaire +3 more sources
Neprilysin Inhibitors and Bradykinin [PDF]
Frontiers in Medicine, 2018 Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury.
Duncan J. Campbell +2 more
doaj +5 more sources
Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease [PDF]
Kidney Research and Clinical Practice, 2021 Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades.
In-Jeong Cho, Seok-Min Kang
doaj +2 more sources
Neural Regeneration Research, 2022 Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj +2 more sources
Autocrine regulation of human sperm motility by tachykinins [PDF]
Reproductive Biology and Endocrinology, 2010 Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M +7 more
doaj +7 more sources
Active site mutations change the cleavage specificity of neprilysin. [PDF]
PLoS ONE, 2012 Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton +4 more
doaj +6 more sources
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice [PDF]
BMC Neuroscience, 2008 Background Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain.
Patrick Christina +9 more
doaj +5 more sources