Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
M.A.S. Medeiros +4 more
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Active site mutations change the cleavage specificity of neprilysin. [PDF]
PLoS ONE, 2012 Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton +4 more
doaj +3 more sources
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts [PDF]
International Journal of General MedicineChengLing Fan,1,2 HongXia Zhou,2 YuFei Pan,3 Dan Lu1 1Medical College, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Baoying Maternal and Child Health Hospital, Yangzhou, Jiangsu ...
Fan C, Zhou H, Pan Y, Lu D
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Neprilysin Inhibitors and Bradykinin
Frontiers in Medicine, 2018 Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury.
Duncan J Campbell
exaly +3 more sources
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin [PDF]
, 2014 The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin ...
Jean Rossier +10 more
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Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications [PDF]
Frontiers in PharmacologyNeprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system.
Xinyue Zhang +5 more
doaj +2 more sources
Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study [PDF]
, 2014 Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness.
Bryan Williams +7 more
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Substance P and Neprilysin in Chronic Pancreatitis [PDF]
, 2012 Background/Aims: We aimed to analyze substance P (SP) and neprilysin (NEP), the membrane metallopeptidase that degrades SP, in chronic pancreatitis (CP).
Giuseppe Mascetta +8 more
core +5 more sources
Phosphodiesterase 9 Inhibition Combined With Valsartan and With Sacubitril/Valsartan in Experimental Ovine Heart Failure [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground LCZ696 (sacubitril/valsartan) antagonizes the renin–angiotensin system while simultaneously augmenting the natriuretic peptides (NPs). Inhibition of phosphodiesterase 9 inhibition (PDE9i), which hydrolyses NP‐generated cGMP may be a more ...
Nicola J. A. Scott +5 more
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Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease [PDF]
Kidney Research and Clinical Practice, 2021 Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades.
In-Jeong Cho, Seok-Min Kang
doaj +1 more source