Results 131 to 140 of about 25,082 (343)

Neuronal neprilysin overexpression is associated with attenuation of Aβ-related spatial memory deficit

open access: yesNeurobiology of Disease, 2006
Converging evidence links abnormally high brain concentrations of amyloid-β peptides (Aβ) to the pathology of Alzheimer's disease (AD). Lowering brain Aβ levels, therefore, is a therapeutic strategy for the treatment of AD.
Raphael Poirier   +6 more
doaj  

Neprilysin, a Novel Target for Ultraviolet B Regulation of Melanogenesis Via Melanocortins [PDF]

open access: bronze, 2000
Édith Aberdam   +3 more
openalex   +1 more source

Survival after myocardial infarction according to left ventricular function and heart failure symptoms

open access: yesESC Heart Failure, EarlyView.
Asymptomatic reduced left ventricular ejection fraction (LVEF) in the acute phase of myocardial infarction (AMI) was associated with up to 20% 1‐year mortality after discharge, substantially higher than in recent post‐MI trials. Symptoms of heart failure (HF) during the index hospitalization was associated with worse outcomes in patients with preserved
Jarle Jortveit   +3 more
wiley   +1 more source

Anti‐amyloid activity of neprilysin in plaque‐bearing mouse models of Alzheimer's disease [PDF]

open access: bronze, 2004
M. Hasan Mohajeri   +5 more
openalex   +1 more source

A multicentre registry of hospitalized patients with acute and chronic heart failure: Study design of the H2‐registry

open access: yesESC Heart Failure, EarlyView.
The H2‐Registry: overview, first results and outlook. Abstract Aims Heart failure (HF) is a highly prevalent condition affecting 1–3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high.
Johannes Leiner   +15 more
wiley   +1 more source

Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain [PDF]

open access: hybrid, 2004
Nobuhisa Iwata   +9 more
openalex   +1 more source

Cost‐utility analysis of add‐on Qili Qiangxin capsules in chronic heart failure with reduced ejection fraction in China

open access: yesESC Heart Failure, EarlyView.
Abstract Aims The study aimed to analyse the cost‐utility of Chinese patent medicine Qili Qiangxin (QLQX) capsules in heart failure with a reduced ejection fraction from the healthcare payer's perspective. Methods and results From the perspective of the healthcare payer, a Markov model was established to estimate the cost‐utility of adding QLQX ...
Lu Wang, Yinglin Wang, Quan Zhao
wiley   +1 more source

525. Therapy for Alzheimer's Disease by Neprilysin Gene Transfer [PDF]

open access: hybrid, 2004
Robert A. Marr   +6 more
openalex   +1 more source

Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]

open access: yes, 2005
Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L.   +4 more
core   +1 more source

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