Results 131 to 140 of about 14,163 (275)

Angiotensin Receptor‐Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Background Pulmonary hypertension (PH) results in increased right ventricular (RV) afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual acting drug, composed of the neprilysin inhibitor sacubitril and the angiotensin receptor ...
Danial Sharifi kia, Evan Benza, T. Bachman, Claire M. Tushak, Kang Kim, M. Simon   +5 more
semanticscholar   +1 more source

Plasma volume status predicting clinical outcomes in patients undergoing transcatheter edge‐to‐edge mitral valve repair

ESC Heart Failure, EarlyView.
Abstract Aims Plasma volume status (PVS) is recognized as a marker of systemic congestion, but its clinical utility in patients with mitral regurgitation (MR) undergoing transcatheter edge‐to‐edge mitral valve repair (M‐TEER) has not been well established. This study aimed to evaluate the prognostic significance of PVS in these patients.
Ai Kagase, Masanori Yamamoto, Takahiro Tokuda, Ryotaku Kawahata, Hiroto Nishio, Tetsuro Shimura, Ryo Yamaguchi, Mitsuru Sago, Yuki Izumi, Mike Saji, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bouta, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Daisuke Hachinohe, Toshiaki Otsuka, Shunsuke Kubo, Kentaro Hayashida, OCEAN‐Mitral Investigators   +30 more
wiley   +1 more source

Dapagliflozin effect on functional mitral regurgitation and myocardial remodelling: The DEFORM trial

ESC Heart Failure, EarlyView.
Abstract Aims Functional mitral regurgitation (FMR) is associated with adverse outcomes in patients with heart failure, and current guideline‐directed medical therapy (GDMT) offers limited efficacy in managing FMR. This study aims to evaluate the therapeutic impact of the sodium‐glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in patients with ...
Zhuoshan Huang, Rui Fan, Shaozhao Zhang, Junlin Zhong, Yiquan Huang, Peihan Xie, Shanshan Yin, Xiaomin Ye, Xinghao Xu, Rihua Huang, Zhenyu Xiong, Yue Guo, Menghui Liu, Yifen Lin, Suhua Li, Xiaoxian Qian, Jinlai Liu, Xiaodong Zhuang, Xinxue Liao   +18 more
wiley   +1 more source

A Test in Context: Neprilysin

Journal of the American College of Cardiology, 2016
Neprilysin is a zinc-dependent endopeptidase. It is ubiquitous in distribution and promiscuous in function, with >50 putative peptide substrates with varying levels of in vitro and/or in vivo evidence of functional relevance. In the first part of this review, we discuss the genetic, structural, substrate, and pathophysiological aspects of neprilysin ...
Antoni Bayes-Genis, Jaume Barallat, A. Mark Richards   +2 more
openaire   +3 more sources

Right ventricular strain predicts outcome in patients receiving sacubitril/valsartan: A sub‐analysis of DISCOVER‐ARNI

ESC Heart Failure, EarlyView.
Angiotensin receptor/Neprilysin inhibitors (ARNI) have shown to considerably improve the clinical outcome of patients with heart failure and reduced ejection fraction (HFrEF). Identifying individuals who may benefit from ARNI the most could markedly enhance patient management.
Maria Concetta Pastore, Giulia Elena Mandoli, Alberto Giannoni, Francesca Rubina Ginetti, Michele Correale, Natale Daniele Brunetti, Andrea Igoren Guaricci, Laura Piscitelli, Anna Degiovanni, Giuseppe Patti, Alessandro Malagoli, Luca Moderato, Erberto Carluccio, Paolo N. Marino, Michele Emdin, Matteo Cameli   +15 more
wiley   +1 more source

The influence of neprilysin on the pathogenesis of sporadic Alzheimer’s disease [PDF]

The approach of this study was to examine the influence of neprilysin on the pathogenesis of sporadic Alzheimer’s disease. In three parts, this study combined standard histologic, immunohistochemical and in-vitro proteolysis experiments.
Hornung, Karen Annette
core   +1 more source

Review Article : Sacubitril/valsartan use for the hospitalist [PDF]

, 2017
The mainstays of therapy for heart failure with reduced ejection fraction (HFrEF) have traditionally been angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB), beta-blockers, aldosterone receptor antagonists, and ...
Hart, James, Littrell, Rachel, Padkins, Mitchell   +2 more
core   +1 more source

Angiotensin-Neprilysin Inhibition in Patients With Mildly Reduced or Preserved Ejection Fraction and Worsening Heart Failure.

Journal of the American College of Cardiology, 2023
R. Mentz, Jonathan H. Ward, A. Hernandez, S. Lepage, D. Morrow, S. Sarwat, K. Sharma, R. Starling, E. Velazquez, K. Williamson, Akshay S. Desai, S. Zieroth, S. Solomon, E. Braunwald   +13 more
semanticscholar   +1 more source

Impact of mitral valve transcatheter edge‐to‐edge repair on haemodynamic parameters in cardiogenic shock

ESC Heart Failure, EarlyView.
Abstract Background Transcatheter edge‐to‐edge repair (TEER) has been shown to be an effective treatment option for patients experiencing cardiogenic shock (CS) with concomitant high‐grade mitral valve regurgitation. However, haemodynamic changes following M‐TEER have not been thoroughly investigated. Afterload mismatch, leading to the deterioration of
Michal Droppa, Dominik Rath, Philippa Jaeger, Ioannis Toskas, Monika Zdanyte, Andreas Goldschmied, Jürgen Schreieck, Meinrad Gawaz, Tobias Geisler   +8 more
wiley   +1 more source

Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis [PDF]

, 2018
Alzheimer's disease, responsible for the vast majority of dementia cases in the elderly population, is caused by accumulation of toxic levels of amyloid β peptide (Aβ) in the brain.
Mohajeri, M., Wolfer, David
core