Results 131 to 140 of about 25,082 (343)
Converging evidence links abnormally high brain concentrations of amyloid-β peptides (Aβ) to the pathology of Alzheimer's disease (AD). Lowering brain Aβ levels, therefore, is a therapeutic strategy for the treatment of AD.
Raphael Poirier+6 more
doaj
Neprilysin, a Novel Target for Ultraviolet B Regulation of Melanogenesis Via Melanocortins [PDF]
Édith Aberdam+3 more
openalex +1 more source
Asymptomatic reduced left ventricular ejection fraction (LVEF) in the acute phase of myocardial infarction (AMI) was associated with up to 20% 1‐year mortality after discharge, substantially higher than in recent post‐MI trials. Symptoms of heart failure (HF) during the index hospitalization was associated with worse outcomes in patients with preserved
Jarle Jortveit+3 more
wiley +1 more source
Anti‐amyloid activity of neprilysin in plaque‐bearing mouse models of Alzheimer's disease [PDF]
M. Hasan Mohajeri+5 more
openalex +1 more source
The H2‐Registry: overview, first results and outlook. Abstract Aims Heart failure (HF) is a highly prevalent condition affecting 1–3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high.
Johannes Leiner+15 more
wiley +1 more source
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism [PDF]
Gillian Rice+4 more
openalex +1 more source
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain [PDF]
Nobuhisa Iwata+9 more
openalex +1 more source
Abstract Aims The study aimed to analyse the cost‐utility of Chinese patent medicine Qili Qiangxin (QLQX) capsules in heart failure with a reduced ejection fraction from the healthcare payer's perspective. Methods and results From the perspective of the healthcare payer, a Markov model was established to estimate the cost‐utility of adding QLQX ...
Lu Wang, Yinglin Wang, Quan Zhao
wiley +1 more source
525. Therapy for Alzheimer's Disease by Neprilysin Gene Transfer [PDF]
Robert A. Marr+6 more
openalex +1 more source
Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]
Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L.+4 more
core +1 more source