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Periodontopathogens degrade angiotensin I from the human renin-angiotensin system through surface-attached proteases. [PDF]
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Copper Downregulates Neprilysin Activity Through Modulation of Neprilysin Degradation
Journal of Alzheimer's Disease, 2010Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study,
Li Mi +6 more
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Tat peptides inhibit neprilysin
Journal of Neurovirology, 2006Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail, Daily +2 more
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Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
A J, Cohen, Y E, Miller
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Neprilysin: Indications, Expectations, and Challenges
Revista Española de Cardiología (English Edition), 2016La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni, Bayes-Genis, Josep, Lupón
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Neprilysin Inhibitors in Cardiovascular Disease
Current Cardiology Reports, 2017Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Guson, Kang, Dipanjan, Banerjee
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