Results 21 to 30 of about 14,163 (275)

Frailty and uptake of angiotensin receptor neprilysin inhibitor for heart failure with reduced ejection fraction

Journal of The American Geriatrics Society, 2023
Frail older adults may be less likely to receive guideline‐directed medical therapy (GDMT)—renin‐angiotensin blockers, beta‐blockers, and mineralocorticoid receptor antagonists—for heart failure with reduced ejection fraction (HFrEF). We aimed to examine
Yu-Chien Lee, Joshua Lin, D. Ko, Susan Cheng, Elisabetta Patorno, R. Glynn, T. Tsacogianis, Dae Hyun Kim   +7 more
semanticscholar   +1 more source

Impact of the angiotensin receptor‐neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls

Journal of Diabetes Investigation, 2023
The possible mechanism of increased urinary C‐peptide due to neprilysin inhibitors is investigated. Neprilysin inhibition blocks degradation of natriuretic peptides, and elicits a natriuretic and antihypertensive effect.
Tomoko Kato, T. Murakami, D. Yabe, N. Harada   +3 more
semanticscholar   +1 more source

The mortality for the implantable cardiac defibrillator in nonischemic cardiomyopathy: An updated systematic review and meta‐analysis

Clinical Cardiology, Volume 45, Issue 12, Page 1163-1170, December 2022., 2022
Abstract The implantable cardiac defibrillator (ICD) is common for the management of nonischemic cardiomyopathy (NICM). Mortality is a crucial issue for patients with NICM. We can understand the mortality events of ICD versus medicine treatment via a systemic review and meta‐analysis of randomized clinical trials.
Wenfeng He, Cheng Xue, Jiankang Zheng, Zhuang Shuai   +3 more
wiley   +1 more source

Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion Via GLP-1 Receptor Signaling in Male Mice.

Endocrinology, 2023
The peptidase neprilysin modulates glucose homeostasis by cleaving and inactivating insulinotropic peptides, including some produced in the intestine such as glucagon-like peptide-1 (GLP-1).
N. Esser, T. Mundinger, Breanne M Barrow, S. Zraika   +3 more
semanticscholar   +1 more source

Neprilysin in HFrEF

JACC: Basic to Translational Science, 2020
[Figure: see text] [Figure: see text]
John C. Burnett, Horng H. Chen
openaire   +3 more sources

Systemic Administration of Lipopolysaccharide from Porphyromonas gingivalis Decreases Neprilysin Expression in the Mouse Hippocampus

In Vivo, 2023
Background/Aim: Alzheimer’s disease is the most common type of neurodegenerative disorder in elderly individuals worldwide. Increasing evidence suggests that periodontal diseases are involved in the pathogenesis of Alzheimer’s disease, and an association
Tetsuro Morikawa, O. Uehara, Durga Paudel, Koki Yoshida, F. Harada, Daichi Hiraki, J. Sato, H. Matsuoka, Y. Kuramitsu, M. Michikawa, Y. Abiko   +10 more
semanticscholar   +1 more source

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction

New England Journal of Medicine, 2021
BACKGROUND: In patients with symptomatic heart failure, sacubitril-valsartan has been found to reduce the risk of hospitalization and death from cardiovascular causes more effectively than an angiotensin-converting-enzyme inhibitor.
M. Pfeffer, B. Claggett, E. Lewis, C. Granger, L. Køber, A. Maggioni, D. Mann, J. McMurray, J. Rouleau, S. Solomon, P. Steg, O. Berwanger, M. Čikeš, C. D. De Pasquale, C. East, A. Fernandez, K. Jering, U. Landmesser, R. Mehran, B. Merkely, F. Vaghaiwalla Mody, M. Petrie, I. Petrov, M. Schou, M. Senni, David Sim, P. van der Meer, M. Lefkowitz, Yinong Zhou, J. Gong, E. Braunwald   +30 more
semanticscholar   +1 more source

Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction

BMC Cardiovascular Disorders, 2020
Background Left ventricular remodeling following ST-elevation myocardial infarction (STEMI) is associated with poor outcome, including heart failure (HF).
Damien Legallois, Clémence Macquaire, Amir Hodzic, Stéphane Allouche, Ismaïl El Khouakhi, Alain Manrique, Paul Milliez, Eric Saloux, Farzin Beygui   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Biomedicines, 2021
Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD.
Dimitris Matiadis, See-Ting Ng, Eric H.-L. Chen, Georgia Nigianni, Veroniki P. Vidali, Aleksander Canko, Rita P.-Y. Chen, Marina Sagnou   +7 more
doaj   +1 more source

Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial

European Heart Journal, 2021
Aims We evaluated the influence of sacubitril/valsartan on the effects of sodium-glucose cotransporter 2 (SGLT2) inhibition with empagliflozin in patients with heart failure and a reduced ejection fraction.
M. Packer, S. Anker, J. Butler, G. Filippatos, J. Ferreira, S. Pocock, H. Rocca, S. Janssens, H. Tsutsui, Jian Zhang, M. Brueckmann, W. Jamal, D. Cotton, T. Iwata, J. Schnee, F. Zannad   +15 more
semanticscholar   +1 more source