Results 81 to 90 of about 446,801 (290)
Prostate International, 2014 Radical prostatectomy (RP) became a first choice of treatment for prostate cancer after the advance in nerve-sparing techniques. However, the difficult technical details still involved in nerve-sparing RP (nsRP) can invite unwanted complications ...
Emre Huri
doaj +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
PREDICTORS OF COMPLETE NERVE SPARING DURING ROBOT-ASSISTED RADICAL PROSTATECTOMY
, 2012 PREDICTORS OF COMPLETE NERVE SPARING DURING ROBOT-ASSISTED RADICAL ...
Chauhan S +9 more
core
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Indian Journal of Urology, 2015 Introduction: We aimed to identify peri-operative and pathologic characteristics that may predict the need for clean intermittent catheterization (CIC) following radical cystectomy (RC) with orthotopic neobladder (ONB) in order to improve patient ...
Katie S Murray +5 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
A systematic review of nerve-sparing surgery for high-risk prostate cancer
, 2021 We provide a systematic analysis of nerve-sparing surgery (NSS) to assess and summarize the risks and benefits of NSS in high-risk prostate cancer (PCa)
Fokin, Igor +30 more
core +1 more source
A Systematic Review of the Effects of Nerve Sparing during Radical Prostatectomy [PDF]
This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement (2009). MEDLINE, EMBASE, The Cochrane Library, Health Technology Assessment Database, and Web of Science were searched from 1966
Shaw, Greg +8 more
core +4 more sources