Results 111 to 120 of about 3,812 (144)

Nerve agent toxicity and treatment

Current Treatment Options in Neurology, 2005
The clinical syndrome of nerve agent toxicity varies widely, ranging from the classic cholinergic syndrome to flaccid paralysis and status epilepticus. All nerve agents are capable of producing marked neuropathology. Seizure control is strongly associated with protection against acute lethality and brain pathology.
Christopher P. Holstege, Stephen G. Dobmeier   +1 more
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Nerve Agents

Neurologic Clinics, 2003
Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as resources for information on nerve ...
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Organophosphate Nerve Agents

2009
Publisher Summary The chemical warfare (CW) nerve agents primarily addressed in this chapter include the anticholinesterase nerve agents tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), and VX, all of which are, or have been, part of the US domestic munitions inventories. These agents are potent anticholinesterase compounds deliberately formulated
Kulbir S. Bakshi, Annetta P. Watson, Robert A. Young, Dennis M. Opresko, Joseph King, Veronique D. Hauschild   +5 more
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Nerve Agents: A Comprehensive Review

Journal of Intensive Care Medicine, 2004
Nerve agents are perhaps the most feared of potential agents of chemical attack. The authors review the history, physical characteristics, pharmacology, clinical effects, and treatment of these agents.
Sage W. Wiener, Robert S. Hoffman
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Inhalational exposure to nerve agents

Respiratory Care Clinics, 2004
The respiratory system plays a major role in the pathogenesis of nerve agent toxicity. It is the major route of entry and absorption of nerve agent vapor, and respiratory failure is the most common cause of death follow-ing exposure. Respiratory symptoms are mediated by chemical irritation,muscarinic and nicotinic receptor overstimulation, and central ...
Stuart A. Roop, Stuart A. Roop, Alexander S. Niven   +2 more
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Toxicokinetics of Nerve Agents

2007
This chapter presents the subjects as in the second edition, updated with the latest results on the toxicokinetics of VX, mainly obtained after improvement of the analytical methodology. Toxicokinetic studies, together with toxicodynamic studies of nerve agents, provide a quantitative basis for the design of new strategies against intoxication with ...
B. J. Lukey, M.J. van der Schans, J. A. Romano, Hendrik P. Benschop, Harry Salem, C. E. Whalley   +5 more
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Chemical warfare agents: II. nerve agents

Annals of Emergency Medicine, 1992
Nerve agents are highly potent and rapidly acting organophosphorus compounds that irreversibly bind and inactive acetylcholinesterase. Only rarely have they been used in warfare, but their great lethality and the threat that they pose have encouraged production and stockpiling in large quantities.
Frederick R Sidell, Jonathan Borak
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Environmental exposure to organophosphorus nerve agents

Environmental Toxicology and Pharmacology, 2017
Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities.
Vučinić, Slavica, Antonijević, Biljana, Tsatsakis, Aristidis, Vassilopoulou, Loukia, Docea, Anca Oana, Nosyrev, Alexander E., Izotov, Boris N., Thiermann, Horst, Drakoulis, Nikolaos, Brkić, Dragica   +9 more
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Therapy for Nerve Agent Poisoning

Archives of Neurology, 2004
Neurologists need to familiarize themselves with nerve agents, the most toxic of the chemical warfare agents. Their mode of action lies within the nervous system, and nonneurologists will look to neurologists for expert advice on therapy. These agents cause rapid-onset cholinergic crisis amenable to prompt treatment with specific antidotes.
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Degradation of nerve agents by an organophosphate-degrading agent (OpdA)

Journal of Hazardous Materials, 2008
Enzyme-catalysed degradation of the nerve agents tabun, sarin, ethyl sarin and soman by three variants of an organophosphate-degrading enzyme was studied at low concentrations of nerve agent. The concentration of nerve agent at a given time was determined by its ability to inhibit the enzyme acetylcholinesterase.
R.M. Dawson, S. Pantelidis, S.E. Kotsonis, H.R. Rose   +3 more
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