Results 91 to 100 of about 1,688,218 (301)

Nerve cell differentiation in hydra requires two signals [PDF]

, 1986
Endogenous signals controlling nerve cell commitment in hydra were investigated using an assay for committed nerve precursors. Extracts of hydra tissue were prepared and tested for their ability to induce nerve cell commitment.
Schaller, Chica H., Holstein, Thomas W., David, Charles N.   +2 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Nerve Agent Degradation Using Polyoxoniobates [PDF]

Polyoxoniobates are exceptional amongst polyoxometalates in that they can potentially perform base catalysis in water, a process in which a proton is bonded to an oxo ligand, and a hydroxyl is released.
Creasy, William R., Nyman, May, Kinnan, Mark K., Schreuder-Gibson, Heidi L., Fullmer, Lauren B.   +4 more
core   +3 more sources

Organophosphate Nerve Agent Detection with Europium Complexes

The Scientific World Journal, 2004
We explore the detection of paraoxon, a model compound for nonvolatile organophosphate nerve agents such as VX. The detection utilizes europium complexes with 1,10 phenanthroline and thenoyltrifluoroacetone as sensitizing ligands.
Jake R. Schwierking, Laird W. Menzel, E. Roland Menzel   +2 more
doaj   +1 more source

An integrated trust and reputation model for open multi-agent systems [PDF]

, 2006
Trust and reputation are central to effective interactions in open multi-agent systems in which agents, that are owned by a variety of stakeholders, continuously enter and leave the system.
Huynh, TD, Jennings, NR, Shadbolt, NR, Jennings, N. R., Huynh, T.D., Shadbolt, N.R.   +5 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

A Porous Metal−Organic Replica of α-PbO₂ for Capture of Nerve Agent Surrogate

, 2016
A novel metal-organic replica of α-PbO2 exhibits high capacity for capture of nerve agent ...
Anthony K. Burrell (1396066), Jonathan L. Cape (2172028), Tatiana V. Timofeeva (1433485), Toti E. Larson (2240848), Ruiqin Zhong (521944), Yusheng Zhao (388357), Donald D. Hickmott (2240851), Songbai Han (2240854), Hongwu Xu (324724), Ruqiang Zou (1351191), Neil Henson (2240845)   +10 more
core   +2 more sources

In Silico Identification of Hit Compound to Counteract A-Series Nerve Agents Poisoning

Chemistry
Organophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by phosphylating the catalytic serine. Oxime reactivators can restore enzymatic activity by a nucleophilic attack of the oximate anion on the ...
Nikola Maraković
doaj   +1 more source

Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin

Journal of Neuroinflammation, 2011
Background Although the acute toxicity of organophosphorus nerve agents is known to result from acetylcholinesterase inhibition, the molecular mechanisms involved in the development of neuropathology following nerve agent-induced seizure are not well ...
Meyerhoff James L, Robison Christopher L, Lumley Lucille A, Spradling Kimberly D, Dillman James F   +4 more
doaj   +1 more source