Hydrolysis and enzymatic degradation of Novichok nerve agents [PDF]
Heliyon, 2020 Several parameters of the Novichok nerve agents A230, A232 and A234 were determined. Hydrolysis rates were approximately one to three orders of magnitude slower than G-type nerve agents and approximately zero to two orders of magnitude slower than V-type
Steve Harvey
exaly +9 more sources
A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management [PDF]
Frontiers in Toxicology, 2023 Background: The whole world has learned about the existence of a highly toxic neuro-paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used during the wars of decades ago, which also had harmful and irreversible effects ...
Amirhosein Charejoo +3 more
exaly +6 more sources
Characterization and Study on Fragmentation Pathways of a Novel Nerve Agent, ‘Novichok (A234)’, in Aqueous Solution by Liquid Chromatography–Tandem Mass Spectrometry [PDF]
Molecules, 2021 As a first step toward studying the properties of Novichok (ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)), we investigated its degradation products and fragmentation pathways in aqueous solution at different pH levels by liquid ...
Jin Young Lee
exaly +5 more sources
Novichok Nerve Agents as Inhibitors of Acetylcholinesterase—In Silico Study of Their Non-Covalent Binding Affinity [PDF]
MoleculesIn silico studies were performed to assess the binding affinity of selected organophosphorus compounds toward the acetylcholinesterase enzyme (AChE). Quantum mechanical calculations, molecular docking, and molecular dynamics (MD) with molecular mechanics
Bartłomiej` Gostynski +2 more
exaly +5 more sources
Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents [PDF]
International Journal of Molecular Sciences, 2021 Organophosphorus nerve agents (OPNAs) are highly toxic compounds inhibiting cholinergic enzymes in the central and autonomic nervous systems and neuromuscular junctions, causing severe intoxications in humans. Medical countermeasures and efficient decontamination solutions are needed to counteract the toxicity of a wide spectrum of harmful OPNAs ...
Martijn de Koning +2 more
exaly +9 more sources
Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma [PDF]
Molecules, 2021 To identify biomarkers of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)- or methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A232)-inhibited butyrylcholinesterase (BChE), we investigated nonapeptide adducts containing the ...
Woo-Hyeon Jeong +2 more
exaly +7 more sources
Theoretical study on the toxicity of ‘Novichok’ agent candidates [PDF]
Royal Society Open Science, 2019 The identities and properties of ‘Novichok’ (Russian for ‘newcomer’ or ‘novice’) agents allegedly used in the recent terrorist attack in the UK have not been well documented. Although several people previously involved in the synthesis of these materials
Junwon Choi, Keunhong Jeong
exaly +4 more sources
Precisely predicting the 1H and 13C NMR chemical shifts in new types of nerve agents and building spectra database [PDF]
Scientific Reports, 2022 Following the recent terrorist attacks using Novichok agents and the subsequent decomposition operations, understanding the chemical structures of nerve agents has become important.
Keunhong Jeong +8 more
doaj +2 more sources
A-agents, misleadingly known as "Novichoks": a narrative review. [PDF]
Arch Toxicol, 2023 Abstract“Novichok” refers to a new group of nerve agents called the A-series agents. Their existence came to light in 2018 after incidents in the UK and again in 2020 in Russia. They are unique organophosphorus-based compounds developed during the Cold War in a program called Foliant in the USSR.
Opravil J +10 more
europepmc +3 more sources
Theoretical prediction on the hydrolysis rate of the new types of nerve agents: A density functional study [PDF]
Toxicology Reports, 2023 Although the hydrolysis mechanism of the nerve agents, which is the main decontamination pathway, has been studied experimentally and theoretically, the reliable theoretical prediction method for the hydrolysis rate is not studied yet. Furthermore, after
Md Al Mamunur Rashid +3 more
doaj +2 more sources