Results 1 to 10 of about 348,995 (347)

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

open access: yesFrontiers in Pharmacology, 2019
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone   +6 more
doaj   +1 more source

The use of VX as a terrorist agent: action by Aum Shinrikyo of Japan and the death of Kim Jong-Nam in Malaysia: four case studies

open access: yesGlobal Security: Health, Science and Policy, 2020
VX is a strong nerve-gas agent. In this paper, murder or injury of human made by VX is reported. First use of VX against human was made by Aum Shimrikyo in 1994 and 1995. More recently, VX was used in the assassination of Mr. Kim Jong-Nam in Kuala Lumpur,
Anthony T. Tu
doaj   +1 more source

Protective agent for retinal nerve or optic nerve [PDF]

open access: yes, 2008
The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods.

core  

Neurotoxicity induced by mephedrone: an up-to-date review [PDF]

open access: yes, 2017
BACKGROUND: Mephedrone is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential.
Busardo', FRANCESCO PAOLO   +6 more
core   +1 more source

Infra-orbital nerve block using alar base approach: A novel landmark and technique

open access: yesJournal of Oral Biology and Craniofacial Research, 2021
The infra-orbital nerve block is given to anaesthetize the anterior part of maxilla by depositing the local anesthetic agent in proximity of the infra-orbital nerve foramen. The two intra-oral approaches well documented in the literature are the ‘central
Jignesh Rajguru   +4 more
doaj   +1 more source

Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]

open access: yes, 2018
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core   +1 more source

Class A drug abuse: an ophthalmologist's problem? [PDF]

open access: yes, 2005
[First Paragraph] The 2002/3 British Crime Survey reported that 3% of all 16 to 59 year olds (equating to around one million people) had used a class A drug in the last year.
Firth, A.Y.
core   +1 more source

Midazolam Efficacy Against Acute Hydrogen Sulfide-Induced Mortality and Neurotoxicity. [PDF]

open access: yes, 2018
Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while
Anantharam, Poojya   +6 more
core   +1 more source

Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase

open access: yesFrontiers in Chemistry, 2014
We applied a combination of rational design and directed evolution (DE) to Bacillus subtilis p-nitrobenzyl esterase (pNBE) with the goal of enhancing organophosphorus acid anhydride hydrolase (OPAAH) activity.
Patricia Marie Legler   +3 more
doaj   +1 more source

Protocol for electrophysiological monitoring of carotid endarterectomies. [PDF]

open access: yes, 2010
Near zero stroke rates can be achieved in carotid endarterectomy (CEA) surgery with selective shunting and electrophysiological neuromonitoring. though false negative rates as high as 40% have been reported.
Di Giorgio, Anthony M   +4 more
core   +2 more sources

Home - About - Disclaimer - Privacy