Results 21 to 30 of about 1,609,891 (295)
Frontiers in Neuroscience, 2021 Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition.
Julia E. Morgan +11 more
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Nerve agents: emergency preparedness [PDF]
BMJ Military Health, 2020 Nerve agents (NAs) are a highly toxic group of chemical warfare agents. NAs are organophosphorus esters with varying physical and chemical properties depending on the individual agent. The most recently developed class of NA is‘Novichok’, the existence of which was first revealed in the early 1990s, just before Russia signed the Chemical Weapons ...
Alan George Andrew Weir +2 more
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A naphthalimide-based fluorescence-enhanced probe for nerve agent mimics
上海师范大学学报. 自然科学版, 2020 Neurotoxic agents, such as sarin, soman and tauben, are highly toxic organophosphorus compounds, which can be used as chemical weapons.These compounds mainly inhibit the activity of acetylcholine enzymes, which in turn cause nervous system disorders ...
ZHAO Lei, CHEN Kang, CHENG Tanyu
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Epilepsia Open, 2023 Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex differences ...
Meghan Gage +6 more
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Thermal Catalytic Decomposition of Dimethyl Methyl Phosphonate Using CuO-CeO2/γ-Al2O3
Applied Sciences, 2022 Chemical warfare agents (CWAs) are highly toxic and fast-acting and are easy to cause large-scale poisoning to humans and livestock after being released. The activated carbon used for CWAs adsorption has disadvantages of limited adsorption capacity, easy
Han Gao +5 more
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Electrochemical Biosensors based on Acetylcholinesterase and Butyrylcholinesterase. A Review
International Journal of Electrochemical Science, 2016 Two cholinesterases are known: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The both enzymes are presented in the body under physiological conditions and the both enzymes have broad use in pharmacology, toxicology and analyses.
Miroslav Pohanka
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Frontiers in Cellular Neuroscience, 2022 Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel
Meghan Gage +10 more
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Science, 2017 Analysis of local honey samples shows global landscape contamination by ...
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Theoretical study on the toxicity of ‘Novichok’ agent candidates [PDF]
Royal Society Open Science, 2019 The identities and properties of ‘Novichok’ (Russian for ‘newcomer’ or ‘novice’) agents allegedly used in the recent terrorist attack in the UK have not been well documented. Although several people previously involved in the synthesis of these materials
Keunhong Jeong, Junwon Choi
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Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma
Molecules, 2021 To identify biomarkers of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)- or methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A232)-inhibited butyrylcholinesterase (BChE), we investigated nonapeptide adducts containing the ...
Woo-Hyeon Jeong +3 more
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