Results 21 to 30 of about 1,688,218 (301)

Theoretical study on the toxicity of ‘Novichok’ agent candidates [PDF]

Royal Society Open Science, 2019
The identities and properties of ‘Novichok’ (Russian for ‘newcomer’ or ‘novice’) agents allegedly used in the recent terrorist attack in the UK have not been well documented. Although several people previously involved in the synthesis of these materials
Keunhong Jeong, Junwon Choi
doaj   +1 more source

Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma

Molecules, 2021
To identify biomarkers of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)- or methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A232)-inhibited butyrylcholinesterase (BChE), we investigated nonapeptide adducts containing the ...
Woo-Hyeon Jeong, Jin-Young Lee, Kyoung-Chan Lim, Hyun-Suk Kim   +3 more
doaj   +1 more source

Social media video analysis methodology for sarin exposure

Forensic Sciences Research, 2020
As social media becomes increasingly ubiquitous, many events are recorded and released on social media platforms, including chemical weapon attacks.
Sadik Toprak, Emine Yilmaz Can, Bulent Altinsoy, John Hart, Zekeriya Dogan, Mustafa Ozcetin   +5 more
doaj   +1 more source

Spatial pattern of nerve differentiation in Hydra is due to a pattern of nerve commitment [PDF]

, 1981
The pattern of nerve differentiation along the body column of Hydra was investigated. Nerve precursors in late S phase were labeled with [3H]thymidine and their distribution compared with that of newly differentiated nerves.
G. Venugopal, Venugopal, G., Charles N. David, David, Charles N.   +3 more
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Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
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Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin [PDF]

, 2009
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholin-ergic crisis. Development of protein-based therapeutics is be-ing pursued with the goal of preventing nerve agent toxicity and ...
Monika Wierdl, Mary Macdonald, Tamara C. Otto, Matthew R. Redinbo, Fleming, C. D., Hemmert, A. C., Douglas M. Cerasoli, MacDonald, M., Cashman, J. R., Christopher D. Fleming, Edwards, C. C., Carol C. Edwards, Andrew C. Hemmert, Wierdl, M., Potter, P. M., Philip M. Potter, Redinbo, M. R., John R. Cashman, Otto, T. C., Cerasoli, D. M.   +19 more
core   +1 more source

Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator

Molecules, 2007
Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used
Jan Marek, Martina Hrabinova, Petr Stodulka, Daniel Jun, Martin Paar, Kamil Musilek, Kamil Kuca   +6 more
doaj   +1 more source

Therapeutic strategy for facial paralysis based on the combined application of Si-based agent and methylcobalamin

Biochemistry and Biophysics Reports, 2022
Facial paralysis results in the decline in the generation of facial expressions and is attributed to several causes. Intractable facial paralysis has a poor prognosis, and new treatments are required.
Yoshihisa Koyama, Shotaro Harada, Takashi Sato, Yuki Kobayashi, Hiroto Yanagawa, Toru Iwahashi, Hiroyuki Tanaka, Kazuya Ohata, Takao Imai, Yumi Ohta, Takefumi Kamakura, Hikaru Kobayashi, Hidenori Inohara, Shoichi Shimada   +13 more
doaj   +1 more source

Detection of Novichok and V-Group Nerve Agents by Chemosensors Containing Nile Blue Chromophore

Chemosensors
This paper presents the results of experiments aiming for the detection and differentiation of selected nerve agents of the Novichok and V-group using simple strip detectors containing colourimetric indicator, specifically chemosensor Nile Blue A ...
Martin Urban, Tomáš Dropa, Markéta Zelenková, Michal Dymák, Vladimír Pitschmann   +4 more
doaj   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Lnk, H., Gratzl, Manfred   +5 more
core   +1 more source