Results 11 to 20 of about 348,995 (347)

Creating realistic nerve agent victim profiles for computer simulation of medical CBRN disaster response [PDF]

Frontiers in Public Health, 2023
In the last decades, Chemical, Biological, Radiological and Nuclear (CBRN) threats have become serious risks prompting countries to prioritize preparedness for such incidents.
Ruben De Rouck, Mehdi Benhassine, Michel Debacker, Christian Dugauquier, Christian Dugauquier, Erwin Dhondt, Filip Van Utterbeeck, Ives Hubloue   +7 more
doaj   +4 more sources

Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase [PDF]

Communications Biology, 2021
Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified ...
Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr, Alan J. Russell   +10 more
doaj   +4 more sources

Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent [PDF]

Frontiers in Cellular Neuroscience
Organophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that
Chandrakumar Bogguri, Vivek Kurien George, Beheshta Amiri, Alexander Ladd, Nicholas R. Hum, Aimy Sebastian, Heather A. Enright, Carlos A. Valdez, T. Nathan Mundhenk, Jose Cadena, Doris Lam   +10 more
doaj   +4 more sources

Qualitative Analysis of Novel Flavonoid Adducts from Nerve Agent Tabun-Exposed Arabidopsis thaliana (L.) Based on Quadrupole–Time of Flight Mass Spectrometry [PDF]

Molecules, 2023
Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers.
Zhongfang Xing, Ruiqian Zhang, Zhehui Zhao, Ling Yuan, Huilan Yu, Yang Yang, Yuntao Yang, Shilei Liu, Chengxin Pei   +8 more
doaj   +2 more sources

Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]

Chemistry, 2022
Lindgren C, Forsgren N, Hoster N, Akfur C, Artursson E, Edvinsson L, Svensson R, Worek F, Ekström F, Linusson A.   +9 more
europepmc   +3 more sources

Synthesis and characterization of nitrogen-doped-MWCNT@cobalt oxide for nerve agent simulant detection. [PDF]

Sci Rep
Lama S, Choi HS, Ramesh S, Lee YJ, Kim JH.   +4 more
europepmc   +3 more sources

Development of Nano Ache Enzyme Based Sensor for Determination of Nerve Agents Used in Chemical Weapons [PDF]

Gazi Üniversitesi Fen Bilimleri Dergisi, 2020
In this study; Nano enzyme system based sensor system has been developed for detection of nerve agents used in chemical weapons production. The chemical substances forming the nerve agents are included in the group of organophosphorus compounds. Paraoxon
Ozan YAĞMUROĞLU, Sibel Emir DİLTEMİZ
doaj   +1 more source

Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure. [PDF]

J Neuroinflammation
Massey N, Vasanthi SS, Holtkamp C, Meyer C, Rao NS, Gimenez-Lirola LG, Wang C, Im H, Bevoor AS, Kannurpatti S, Thippeswamy T.   +10 more
europepmc   +3 more sources

Wireless Hazard Badges to Detect Nerve‐Agent Simulants

Angewandte Chemie - International Edition, 2016
Rong Zhu, Joseph M. Azzarelli, Timothy M. Swager   +2 more
openalex   +4 more sources

Leveraging Dissolution by Autoinjector Designs

Pharmaceutics, 2022
Chemical warfare or terrorism attacks with organophosphates may place intoxicated subjects under immediate life-threatening and psychologically demanding conditions.
Christoph Spangardt, Christoph Keßler, Ramona Dobrzewski, Antonia Tepler, Simon Hanio, Bernd Klaubert, Lorenz Meinel   +6 more
doaj   +1 more source