Results 41 to 50 of about 1,609,891 (295)

Shoulder posture and median nerve sliding [PDF]

, 2004
Background: Patients with upper limb pain often have a slumped sitting position and poorshoulder posture. Pain could be due to poor posture causing mechanical changes (stretch; localpressure) that in turn affect the function of major limb nerves (e.g ...
Lees, R, Julius, A, Lees Rebecca, Lynn Bruce, Lynn, B, Dilley, A, Julius Andrea, Dilley Andrew   +7 more
core   +1 more source

Detection of Novichok and V-Group Nerve Agents by Chemosensors Containing Nile Blue Chromophore

Chemosensors
This paper presents the results of experiments aiming for the detection and differentiation of selected nerve agents of the Novichok and V-group using simple strip detectors containing colourimetric indicator, specifically chemosensor Nile Blue A ...
Martin Urban, Tomáš Dropa, Markéta Zelenková, Michal Dymák, Vladimír Pitschmann   +4 more
doaj   +1 more source

Therapeutic strategy for facial paralysis based on the combined application of Si-based agent and methylcobalamin

Biochemistry and Biophysics Reports, 2022
Facial paralysis results in the decline in the generation of facial expressions and is attributed to several causes. Intractable facial paralysis has a poor prognosis, and new treatments are required.
Yoshihisa Koyama, Shotaro Harada, Takashi Sato, Yuki Kobayashi, Hiroto Yanagawa, Toru Iwahashi, Hiroyuki Tanaka, Kazuya Ohata, Takao Imai, Yumi Ohta, Takefumi Kamakura, Hikaru Kobayashi, Hidenori Inohara, Shoichi Shimada   +13 more
doaj   +1 more source

Nerve cell differentiation in hydra requires two signals [PDF]

, 1986
Endogenous signals controlling nerve cell commitment in hydra were investigated using an assay for committed nerve precursors. Extracts of hydra tissue were prepared and tested for their ability to induce nerve cell commitment.
Schaller, Chica H., Holstein, Thomas W., David, Charles N.   +2 more
core   +1 more source

Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure. [PDF]

J Neuroinflammation
Background: Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately. Existing medical countermeasures (MCMs- atropine, oximes,
Massey N, Vasanthi SS, Holtkamp C, Meyer C, Rao NS, Gimenez-Lirola LG, Wang C, Im H, Bevoor AS, Kannurpatti S, Thippeswamy T.   +10 more
europepmc   +2 more sources

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. [PDF]

PLoS ONE, 2011
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning.
Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo   +14 more
doaj   +1 more source

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Frontiers in Pharmacology, 2019
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone, Hilary S. McCarren, Jay Spampanato, F. Edward Dudek, John H. McDonough, Derk Hogenkamp, Kelvin W. Gee   +6 more
doaj   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

The use of VX as a terrorist agent: action by Aum Shinrikyo of Japan and the death of Kim Jong-Nam in Malaysia: four case studies

Global Security: Health, Science and Policy, 2020
VX is a strong nerve-gas agent. In this paper, murder or injury of human made by VX is reported. First use of VX against human was made by Aum Shimrikyo in 1994 and 1995. More recently, VX was used in the assassination of Mr. Kim Jong-Nam in Kuala Lumpur,
Anthony T. Tu
doaj   +1 more source

A Methodology for Agent-Oriented Analysis and Design

, 1999
This paper presents a methodology for agent-oriented analysis and design. The methodology is general, in that it is applicable to a wide range of multi-agent systems, and comprehensive, in that it deals with both the macro-level (societal) and the micro ...
Kinny, D., Jennings, N. R., Kinny, D, Nicholas R. Jennings, Michael Wooldridge, David Kinny, Jennings, NR, Wooldridge, M, Wooldridge, M.   +8 more
core   +1 more source