Results 61 to 70 of about 1,688,218 (301)
Antioxidant drug therapy as a neuroprotective countermeasure of nerve agent toxicity
Neurobiology of Disease, 2020 The use of chemical warfare agents is an ongoing, significant threat to both civilians and military personnel worldwide. Nerve agents are by far the most formidable toxicants in terms of their lethality and toxicity.
Jennifer N. Pearson-Smith, Manisha Patel
doaj +1 more source
Successful use of axonal transport for drug delivery by synthetic molecular vehicles [PDF]
, 2008 We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules.
Mark Bacon +12 more
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Nerve Agents and Their Detection [PDF]
Journal of Sensor Science and Technology, 2014 Nerve agents are major chemical warfare agents with the “G series” and “V series” being the most widely known because of their lethal effect. Although not conspicuously used in major wars, the potential detrimental impact on modern society had been revealed from the sarin terror attack on Tokyo subway, which affected thousands of people.
Young Jun Kim, Jae Doo Huh
openaire +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Acta Medica, 1998 1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly
Jiří Kassa
doaj +1 more source
Protective agent for retinal nerve or optic nerve [PDF]
, 2009 To provide a protective agent for a retinal nerve or an optic nerve, which exhibits its efficacy through a mechanism that is different from that for a conventional therapeutic agent and can be ingested over a long period.
core
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
LABORATORY EXAMINATION IN NERVE AGENT INTOXICATION
Acta Medica, 2013 Diagnosis of nerve agent intoxication is based on anamnestic data, clinical signs and laboratory examination. For acute poisoning, cholinesterase activity in the blood (erythrocyte AChE, plasma/serum BuChE) is sensitive, simple and most frequent ...
Jiří Bajgar
doaj +1 more source
, 2017 Facile and visual detection of a nerve agent mimic by ratiometric fluorescent sensors.
Chen Li, Yuan-Chao Cai, Qin-Hua Song
core +1 more source