Characterization and Study on Fragmentation Pathways of a Novel Nerve Agent, ‘Novichok (A234)’, in Aqueous Solution by Liquid Chromatography–Tandem Mass Spectrometry [PDF]
Molecules, 2021 As a first step toward studying the properties of Novichok (ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)), we investigated its degradation products and fragmentation pathways in aqueous solution at different pH levels by liquid ...
Jin Young Lee
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A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management [PDF]
Frontiers in Toxicology, 2023 Background: The whole world has learned about the existence of a highly toxic neuro-paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used during the wars of decades ago, which also had harmful and irreversible effects ...
Amirhosein Charejoo +3 more
doaj +4 more sources
Forensic Sciences, 2023 Novichok-like or fourth-generation agents (FGAs) are chemical warfare agents (CWAs) which have been gaining attention since their use in assassination attempts on Sergei Skripal and Alexei Navalny.
Gerald Bauer, Christophe Curty
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Novichok Nerve Agents as Inhibitors of Acetylcholinesterase—In Silico Study of Their Non-Covalent Binding Affinity [PDF]
MoleculesIn silico studies were performed to assess the binding affinity of selected organophosphorus compounds toward the acetylcholinesterase enzyme (AChE). Quantum mechanical calculations, molecular docking, and molecular dynamics (MD) with molecular mechanics
Rafal Madaj +3 more
doaj +3 more sources
Hydrolysis and enzymatic degradation of Novichok nerve agents [PDF]
Heliyon, 2020 Several parameters of the Novichok nerve agents A230, A232 and A234 were determined. Hydrolysis rates were approximately one to three orders of magnitude slower than G-type nerve agents and approximately zero to two orders of magnitude slower than V-type
Steve Harvey
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Journal of Chromatography OpenIn this work, studies on the neutralization of Novichok A-234, a member of a class of nerve agents known for their high toxicity, were carried out.
Paula Vanninen +2 more
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Physchem, 2023 The flexible models of Novichok agents (A230, A232, and A234) from previous molecular dynamics simulations (MDSs) have been employed to create a parameter set for the Antoine equation of each of the three liquids. Furthermore, for the needs of this paper,
Michail Chalaris
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Selected Political Criminal Poisonings in the Years 1978–2020: Detection and Treatment [PDF]
Toxics, 2022 Criminal poisonings are among the least frequently detected crimes in the world. Lack of suspicion of this type of event by police officers and prosecutors, clinical symptoms imitating many somatic diseases and technical difficulties in diagnostics, as ...
Zuzanna Brunka +8 more
doaj +3 more sources
The Blurred Lines Between New Psychoactive Substances and Potential Chemical Weapons [PDF]
ToxicsThe historical use of toxic chemicals to cause intentional harm has evolved from blister agents in World War I to highly lethal organophosphates and emerging families of chemicals, such as Novichok.
Loreto N. Valenzuela-Tapia +7 more
doaj +3 more sources
Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma [PDF]
Molecules, 2021 To identify biomarkers of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234)- or methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A232)-inhibited butyrylcholinesterase (BChE), we investigated nonapeptide adducts containing the ...
Woo Hyeon Jeong +2 more
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