Results 161 to 170 of about 205,418 (209)

Toxicokinetics of Nerve Agents

2007
This chapter presents the subjects as in the second edition, updated with the latest results on the toxicokinetics of VX, mainly obtained after improvement of the analytical methodology. Toxicokinetic studies, together with toxicodynamic studies of nerve agents, provide a quantitative basis for the design of new strategies against intoxication with ...
B. J. Lukey, M.J. van der Schans, J. A. Romano, Hendrik P. Benschop, Harry Salem, C. E. Whalley   +5 more
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Chemical warfare agents: II. nerve agents

Annals of Emergency Medicine, 1992
Nerve agents are highly potent and rapidly acting organophosphorus compounds that irreversibly bind and inactive acetylcholinesterase. Only rarely have they been used in warfare, but their great lethality and the threat that they pose have encouraged production and stockpiling in large quantities.
Frederick R Sidell, Jonathan Borak
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Environmental exposure to organophosphorus nerve agents

Environmental Toxicology and Pharmacology, 2017
Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities.
Vučinić, Slavica, Antonijević, Biljana, Tsatsakis, Aristidis, Vassilopoulou, Loukia, Docea, Anca Oana, Nosyrev, Alexander E., Izotov, Boris N., Thiermann, Horst, Drakoulis, Nikolaos, Brkić, Dragica   +9 more
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Therapy for Nerve Agent Poisoning

Archives of Neurology, 2004
Neurologists need to familiarize themselves with nerve agents, the most toxic of the chemical warfare agents. Their mode of action lies within the nervous system, and nonneurologists will look to neurologists for expert advice on therapy. These agents cause rapid-onset cholinergic crisis amenable to prompt treatment with specific antidotes.
openaire   +3 more sources

Degradation of nerve agents by an organophosphate-degrading agent (OpdA)

Journal of Hazardous Materials, 2008
Enzyme-catalysed degradation of the nerve agents tabun, sarin, ethyl sarin and soman by three variants of an organophosphate-degrading enzyme was studied at low concentrations of nerve agent. The concentration of nerve agent at a given time was determined by its ability to inhibit the enzyme acetylcholinesterase.
R.M. Dawson, S. Pantelidis, S.E. Kotsonis, H.R. Rose   +3 more
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Behavioral toxicity of nerve agents

2009
Publisher Summary Behavioral changes in humans are exposed to highly toxic organophosphorus (OP) compounds, called nerve agents. The incidence of behavioral effects is higher in individuals who have been severely exposed to nerve agents, but they may occur in individuals who have received a small exposure and have no or minimal physical signs and ...
Jiri Kassa, Daniel Jun, Jiri Bajgar, Kamil Kuca   +3 more
openaire   +2 more sources

Sixty seconds on . . . nerve agents [PDF]

BMJ, 2018
The recent attack on Russian former double agent Sergei Skripal and his daughter Yulia with a nerve agent has triggered a meeting of the government’s COBRA emergency committee. A huge clean-up effort by specially trained troops has also been launched to minimise any remaining risk in Salisbury. Back to your biochemistry classes!
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Perhydrolysis of nerve agent VX

The Journal of Organic Chemistry, 1993
The exceedingly toxic nerve agent VX (O-ethyl S-(2-diisopropymino)ethyl methylphosphonothioate) cannot be detoxified by reaction with hydroxide ion but is rapidly detoxified by perhydrolysis (substitution with HO 2 - ) presumably via an intramolecular oxygen transfer which precludes loss of the ethoxy ...
Linda L. Szafraniec, Yu Chu Yang, William T. Beaudry, Clifford A. Bunton   +3 more
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Efficacy of Tacrine as a Nerve Agent Pretreatment

Drug and Chemical Toxicology, 1994
Tacrine (THA) was evaluated in vitro and in vivo as a pretreatment for nerve agent intoxication. In vitro experiments showed that the primary effect of THA was direct inhibition of purified fetal bovine serum acetylcholinesterase (AChE) with a slight effect on slowing the aging rate of nerve agent-inhibited AChE.
Koplovitz I, James A. Blank, D. W. Hobson, Fricke Rf, Rockwood Ga, Carl T. Olson, Scharf Ba   +6 more
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Resuscitative challenges in nerve agent poisoning

European Journal of Emergency Medicine, 2003
The threat of weapons of mass destruction such as nerve agents has become real since last year. The medical community has established protocols for the rapid evacuation and decontamination of affected civilians. However, protocols for resuscitative measures or acute perioperative care in cases of life-saving surgical interventions in toxic-traumatized ...
Avi A. Weinbroum, Ron Ben Abraham
openaire   +3 more sources