Results 221 to 230 of about 4,225,584 (267)
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Nerve agent toxicity and treatment
Current Treatment Options in Neurology, 2005The clinical syndrome of nerve agent toxicity varies widely, ranging from the classic cholinergic syndrome to flaccid paralysis and status epilepticus. All nerve agents are capable of producing marked neuropathology. Seizure control is strongly associated with protection against acute lethality and brain pathology.
Christopher P. Holstege+1 more
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Neurologic Clinics, 2003
Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as resources for information on nerve ...
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Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as resources for information on nerve ...
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Nerve Agents: A Comprehensive Review
Journal of Intensive Care Medicine, 2004Nerve agents are perhaps the most feared of potential agents of chemical attack. The authors review the history, physical characteristics, pharmacology, clinical effects, and treatment of these agents.
Sage W. Wiener, Robert S. Hoffman
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Inhalational exposure to nerve agents
Respiratory Care Clinics, 2004The respiratory system plays a major role in the pathogenesis of nerve agent toxicity. It is the major route of entry and absorption of nerve agent vapor, and respiratory failure is the most common cause of death follow-ing exposure. Respiratory symptoms are mediated by chemical irritation,muscarinic and nicotinic receptor overstimulation, and central ...
Stuart A. Roop+2 more
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Toxicokinetics of Nerve Agents
2007This chapter presents the subjects as in the second edition, updated with the latest results on the toxicokinetics of VX, mainly obtained after improvement of the analytical methodology. Toxicokinetic studies, together with toxicodynamic studies of nerve agents, provide a quantitative basis for the design of new strategies against intoxication with ...
B. J. Lukey+5 more
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Nerve Agents: What They Are, How They Work, How to Counter Them.
ACS Chemical Neuroscience, 2018Nerve agents are organophosphorus chemical warfare agents that exert their action through the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of cholinergic transmission followed by its shutdown.
S. Costanzi+2 more
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Chemical warfare agents: II. nerve agents
Annals of Emergency Medicine, 1992Nerve agents are highly potent and rapidly acting organophosphorus compounds that irreversibly bind and inactive acetylcholinesterase. Only rarely have they been used in warfare, but their great lethality and the threat that they pose have encouraged production and stockpiling in large quantities.
Frederick R Sidell, Jonathan Borak
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ACS Catalysis, 2019
Recent studies have suggested that the gas-phase hydrolysis of nerve agents by Zr-based metal–organic frameworks (MOFs) may be limited by product inhibition resulting from strong bidentate binding of the hydrolysis products to the Zr6-nodes.
Matthew L. Mendonca, R. Snurr
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Recent studies have suggested that the gas-phase hydrolysis of nerve agents by Zr-based metal–organic frameworks (MOFs) may be limited by product inhibition resulting from strong bidentate binding of the hydrolysis products to the Zr6-nodes.
Matthew L. Mendonca, R. Snurr
semanticscholar +1 more source
Therapy for Nerve Agent Poisoning
Archives of Neurology, 2004Neurologists need to familiarize themselves with nerve agents, the most toxic of the chemical warfare agents. Their mode of action lies within the nervous system, and nonneurologists will look to neurologists for expert advice on therapy. These agents cause rapid-onset cholinergic crisis amenable to prompt treatment with specific antidotes.
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Recent Advances in the Development of Chromophore-Based Chemosensors for Nerve Agents and Phosgene.
ACS Sensors, 2017The extreme toxicity and ready accessibility of nerve agents and phosgene has caused an increase in the demand to develop effective systems for the detection of these substances.
Liyan Chen, Di Wu, Juyoung Yoon
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