Results 71 to 80 of about 431,436 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Trends in the availability and usage of electrophysical agents in physiotherapy practices from 1990 to 2010: A review [PDF]

, 2012
This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 Maney PublishingBackground: The use of electrophysical agents has a historically important role in physiotherapy practice.
Alexandra Farrow, Chipchase LS, Cooney M, Hayne CR, John L, Kitchen SS, Kitchen SS, Liisa LaaksoE, Lindsay D, Paterson WP, Paxton SL, Quirk AS, Robinson AJ, Rubin A, Sinkus VH, Syed Ghulam Sarwar Shah   +15 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase

Molecules, 2020
The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population.
Franz Worek, Horst Thiermann, Marianne Koller, Timo Wille   +3 more
doaj   +1 more source

Digital dissection of the model organism Xenopus laevis using contrast-enhanced computed tomography [PDF]

, 2017
The African clawed frog, Xenopus laevis, is one of the most widely used model organisms in biological research. However, the most recent anatomical description of X. laevis was produced nearly a century ago.
Ahn, Burgess, Burggren, Cannatella, Cannatella, Clemente, Cline, Cox, Cox, Descamps, Dijk, Diogo, Dunlap, Düring, Ecker, Emerson, Emerson, Evans, Gignac, Green, Grobbelaar, Gross, Gurdon, Gurdon, Gurdon, Harland, Hass, Hautier, Hellsten, Holliday, Jeffery, Johnston, Kargo, Kleinteich, Lautenschlager, Lautenschlager, Mason, Metscher, Metscher, Metscher, Minkoff, Palmer, Paterson, Porro, Pyron, Přikryl, Quayle, Reilly, Richards, Robovská-Havelková, Robovská-Havelková, Roček, Ročkova, Ryke, Sassoon, Session, Smirnov, Trueb, Tsai, Wheeler, Whiting, Ziermann, Ziermann   +62 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hydrophobic Fluorinated Porous Organic Frameworks for Enhanced Adsorption of Nerve Agents

Applied Sciences, 2020
Humidity in the air can significantly limit the adsorption capacity of porous materials used for the removal of chemical warfare agents (CWAs). Therefore, in this work, we prepared a porous organic material (C-1) and its fluoride derivative (C-1-F) via a
Shuyuan Zhou, Weimin Kong, Kunpeng Wang, Hao Han, Derui Yang, Yue Zhao, Hong Zhou, Qinghao Meng, Ye Yuan   +8 more
doaj   +1 more source

SENSORY REGRESSION TIME FROM SUBARACHNOID BLOCK WITH HYPERBARIC 0.75% BUPIVACAINE IN THE OBESE PATIENT [PDF]

, 1989
The purpose of this study was to determine if obese patients have a different sensory regression time from subarachnoid block than non-obese patients using hyperbaric 0.75% bupivacaine. A quasi-experimental design was used. Twenty patients were separated
Hilton, George Leslie
core   +1 more source

Comparison of Post-injection Site Pain Between Technetium Sulfur Colloid and Technetium Tilmanocept in Breast Cancer Patients Undergoing Sentinel Lymph Node Biopsy. [PDF]

, 2015
BackgroundNo prior studies have examined injection pain associated with Technetium-99m Tilmanocept (TcTM).MethodsThis was a randomized, double-blinded study comparing postinjection site pain between filtered Technetium Sulfur Colloid (fTcSC) and TcTM in ...
Baker, Jennifer L, Hoh, Carl K, Hosseini, Ava, Unkart, Jonathan T, Vera, David R, Wallace, Anne M, Wallace, Mark S   +6 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source