Results 241 to 250 of about 1,223,403 (400)

Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study [PDF]

, 2010
Sarabjit Kaur Saggu, Hiren P Chotaliya, Peter Blumbergs, Robert J. Casson   +3 more
openalex   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

Fate of myelin lipids during degeneration and regeneration of peripheral nerve: an autoradiographic study

, 1994
Jeffry F. Goodrum, Todd S. Earnhardt, Nelson D. Goines, Thomas W. Bouldin   +3 more
openalex   +2 more sources

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Leber hereditary optic neuropathy: Mitochondrial mutations and degeneration of the optic nerve

, 1997
Neil Howell
openalex   +1 more source

Detection of retinal nerve fiber layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarkers [PDF]

, 2014
M BAMBO, Elena García‐Martín, Juan Pinilla, Raquel Herrero, María Satué, Sofía Otín, Isabel Fuertes, Marcia L. Marques, Luís E. Pablo   +8 more
openalex   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

The Effects of Disease-Modifying Therapies on Optic Nerve Degeneration in Multiple Sclerosis. [PDF]

Eur J Neurol
Zhang X, Song S, Chen B, Leocani L, Zhao X, Zhong Y, Pisa M, Sharma SM.   +7 more
europepmc   +1 more source

Very Early Involvement of Innate Immunity in Peripheral Nerve Degeneration in SOD1-G93A Mice. [PDF]

Front Immunol, 2020
Angelini DF, De Angelis F, Vacca V, Piras E, Parisi C, Nutini M, Spalloni A, Pagano F, Longone P, Battistini L, Pavone F, Marinelli S.   +11 more
europepmc   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source