Results 241 to 250 of about 1,249,880 (378)

Neuroglobin effectively halts vision loss in Harlequin mice at an advanced stage of optic nerve degeneration

, 2021
Hélène Cwerman‐Thibault, Christophe Lechauve, Vassilissa Malko-Baverel, Sébastien Augustin, Gwendoline Le Guilloux, Élodie Reboussin, Julie Dégardin-Chicaud, Manuel Simonutti, Thomas Debeir, Marisol Corral‐Debrinski   +9 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. [PDF]

Mol Neurobiol, 2020
Kitaoka Y, Sase K, Tsukahara C, Fujita N, Arizono I, Takagi H.   +5 more
europepmc   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

The Multi-targeted Effect of Fascaplysin on the Proliferation and Dedifferentiation of Schwann Cells Inhibits Peripheral Nerve Degeneration by Blocking CDK4/6 and Androgen Receptor. [PDF]

Exp Neurobiol
Chung HJ, Kim JE, Huh Y, Lee JS, Kim SW, Na K, Kim J, Lee SH, Konishi H, Yeo SG, Yon DK, Kim D, Jung J, Jeong NY.   +13 more
europepmc   +1 more source

NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury

, 2019
Zhou Zhang, Wenyi Liu, Yubin Huang, Linlin Luo, Xiaofeng Cai, Yunjia Liu, Liqianyu Ai, Jun Yan, Sen Lin, Jian Ye   +9 more
openalex   +2 more sources

Association of calcium buffering capacity and local inflammatory reactions in injury of motor neurons [PDF]

, 2010
Paizs Melinda
core  

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration. [PDF]

Int Ophthalmol
Otsubo M, Sase K, Tsukahara C, Fujita N, Arizono I, Tokuda N, Kitaoka Y.   +6 more
europepmc   +1 more source

Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons [PDF]

, 1998
Jon Jatsu Azkue, M. Zimmermann, Tsui-Fen Hsieh, Thomas Herdegen   +3 more
openalex   +1 more source