Results 271 to 280 of about 1,223,403 (400)

Regulation of the synthesis of nerve growth factor (NGF) by interleukin-1 (IL-1) [PDF]

, 1992
Bandtlow, Christine, Dantzer, Robert D., Heumann, Rolf, Lindholm, Dan, Meyer, Michael, Rowthwell, Nancy, Thoenen, Hans   +6 more
core   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. [PDF]

Mol Neurobiol, 2020
Kitaoka Y, Sase K, Tsukahara C, Fujita N, Arizono I, Takagi H.   +5 more
europepmc   +1 more source

Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve [PDF]

, 2016
Melissa Gresle, Yaou Liu, Trevor J. Kilpatrick, Dennis Kemper, Qizhu Wu, Bing Hu, Qing‐Ling Fu, Kwok‐Fai So, Guoqing Sheng, Guanrong Huang, Blake Pepinsky, Helmut Butzkueven, Sha Mi   +12 more
openalex   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration. [PDF]

Int Ophthalmol
Otsubo M, Sase K, Tsukahara C, Fujita N, Arizono I, Tokuda N, Kitaoka Y.   +6 more
europepmc   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: A comparative study

, 2009
Guillermo Parrilla-Reverter, Marta Agudo‐Barriuso, Francisco M. Nadal‐Nicolás, Luis Alarcón-Martínez, Manuel Jiménez-López, Manuel Salinas‐Navarro, Paloma Sobrado‐Calvo, José Manuel Bernal-Garro, María Paz Villegas‐Pérez, Manuel Vidal‐Sanz   +9 more
openalex   +1 more source

Ouabain-Induced Cochlear Nerve Degeneration: Synaptic Loss and Plasticity in a Mouse Model of Auditory Neuropathy

The Journal of Laryngology & Otology, 2014
Ya-sheng Yuan, Fanglu Chi
semanticscholar   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source