Results 291 to 300 of about 1,223,403 (400)
Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils
Aggregate, EarlyView.This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky +3 more
wiley +1 more source
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury
, 2014 Dengbing Yao +6 more
openalex +1 more source
Advanced Intelligent Systems, EarlyView.Inspired by the eye movements of humans, a multi‐degree‐of‐freedom (multi‐DOF) miniature piezoelectric actuator with a square‐circular ring structure is proposed. The actuator demonstrates a well‐balanced performance in miniaturization, operational efficiency, actuation precision, and load‐driving capability.
Binbin Zhu, Yan Qing Wang
wiley +1 more source
Case Report: Hypomyelinating Leukodystrophy Type 20 (HLD20) With Novel CNP Gene Variant
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT This case report describes a child with hypomyelinating leukodystrophy type 20 (HLD20), a rare neurodegenerative disorder characterized by impaired myelin formation. The patient presented with multiple neurodevelopmental abnormalities, including delayed motor milestones, seizures, and abnormal facial features.
Malak Alghamdi +7 more
wiley +1 more source
Alzheimer's &Dementia, EarlyView.Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri +10 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source