Results 71 to 80 of about 656,722 (293)

A study of retrograde degeneration of median nerve forearm segment in carpal tunnel syndrome of variable severities

Alexandria Journal of Medicine, 2014
Introduction: Carpal tunnel syndrome (CTS) is a disorder of the hand which results from compression of the median nerve within its fibro-osseous tunnel at the wrist. The slowing in the forearm motor conduction velocity suggests the presence of retrograde
Mona Mokhtar El Bardawil, Gihan Abd El Latief Younis, Marwa Mohammed Hassan, Eman Ramadan Mohammed   +3 more
doaj   +1 more source

Cutaneous Nerve Terminal Degeneration in Painful Mononeuropathy

, 2009
Nociceptive nerves innervate the skin and play an important role in the generation of neuropathic pain. However, it remains elusive whether and how nociceptive nerve terminals degenerate in neuropathic pain conditions.
LIN, YU-WEN;TSENG, TO-JUNG;LIN, WHEI- MIN;HSIEH, SUNG-TSANG, 林玉雯;曾拓榮;林慧敏;謝松蒼   +1 more
core  

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Axonal protection by short-term hyperglycemia with involvement of autophagy in TNF-induced optic nerve degeneration

Frontiers in Cellular Neuroscience, 2015
Previous reports showed that short-term hyperglycemia protects optic nerve axons in a rat experimental hypertensive glaucoma model. In this study, we investigated whether short-term hyperglycemia prevents tumor necrosis factor (TNF)-induced optic nerve ...
Kana eSase, Yasushi eKitaoka, Yasushi eKitaoka, Yasunari eMunemasa, Kaori eKojima, Hitoshi eTakagi   +5 more
doaj   +1 more source

Wallerian Degeneration in Peripheral Nerve Disease

Neurologic Clinics, 1992
Wallerian-like degeneration can be regarded as the final shared pathway of the most prevalent diseases of the peripheral nervous system, including many degenerative, metabolic, heritable, toxic, inflammatory and ischaemic disorders. The cellular responses that take place during Wallerian degeneration, including the elaboration of neurotrophins, are ...
V, Chaudhry, J D, Glass, J W, Griffin
openaire   +3 more sources

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Cell-based therapies for traumatic optic neuropathy: Recent advances, challenges, and perspectives

Neural Regeneration Research
Traumatic optic neuropathy is a form of optic neuropathy resulting from trauma. Its pathophysiological mechanisms involve primary and secondary injury phases, leading to progressive retinal ganglion cell loss and axonal degeneration. Contributing factors
Yuanhui Wang, Moxin Chen, Zhimin Tang, Ping Gu   +3 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration

Journal of Orthopaedic Surgery and Research, 2017
Background Growth of nerve fibers has been shown to occur in a rabbit model of intravertebral disc degeneration (IVD) induced by needle puncture. As nerve growth may underlie the process of chronic pain in humans affected by disc degeneration, we sought ...
Long Xin, Weixing Xu, Leijun Yu, Shunwu Fan, Wei Wang, Fang Yu, Zhenbin Wang   +6 more
doaj   +1 more source

Peripheral Facial Nerve Axotomy in Mice Causes Sprouting of Motor Axons Into Perineuronal Central White Matter: Time Course and Molecular Characterization [PDF]

, 2010
Generation of new axonal sprouts plays an important role in neural repair In the current study, we examined the appearance, composition and effects of gene deletions on intrabrainstem sprouts following peripheral facial nerve axotomy Axotomy was followed
Werner, A, Galiano, Mathias, Ruff, Crystal, Mathias Galiano, Werner, A., Gonitel, R, Werner, Alexander, Anderson, P., Raivich, G., Patrick N. Anderson, Prakasham Rumajogee, Pararajasingam, A, Bohatschek, M, Behrens, A, Galiano, M., Cuthill, Dan, Bohatschek, M., Acosta-Saltos, A, Makwana, Milan, Dan Cuthill, Rumajogee, P., Anderson, Patrick N., Wallace, A. S., Ulrike Mayer, Acosta-Saltos, Alejandro, Anderson, PN, Behrens, Axel, Raivich, Gennadij, Pararajasingham, A, Gonitel, R., Anderson, P. N., Rumajogee, Prakasham, Ruff, C., Ruff, C, Rumajogee, P, Wallace, AS, Acosta-Saltos, A., Alejandro Acosta‐Saltos, Marion Bohatschek, Axel Behrens, Makwana, M, Wallace, Adam S., Bohatschek, Marion, Gennadij Raivich, Mayer, U, Mayer, Ulrike, Wallace, A., Alexander Werner, Adam S. Wallace, Pararajasingham, Abirami, Behrens, A., Abirami Pararajasingham, Makwana, M., Cuthill, D., Crystal Ruff, Cuthill, D, Galiano, M, Gonitel, Roman, Roman Gonitel, Mayer, U., Milan Makwana, Pararajasingham, A., Raivich, G   +62 more
core   +1 more source