Results 31 to 40 of about 23,201 (210)

Sensory-specific peripheral nerve pathology in a rat model of Fabry disease

Neurobiology of Pain, 2021
Fabry disease (FD) causes life-long pain, the mechanisms of which are unclear. Patients with FD have chronic pain that mirrors symptoms of other painful peripheral neuropathies. However, it is unclear what underlying damage occurs in FD peripheral nerves
Tyler B. Waltz, Anthony J. Burand, Jr., Katelyn E. Sadler, Cheryl L. Stucky   +3 more
doaj   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Changes in myelinated fibers in the hippocampus of streptozotocin-induced diabetic rats: a stereological investigation

Folia Morphologica
Diabetes causes cognitive impairment, and the hippocampus is important for long-term and permanent memory function. However, the mechanism of their interaction is still unclear.
Hui Zhao, Ting Zhang, Feng Zhao, Min Tan, Shijuan Du, Yunzi Wang, Juan Li, Jiang Du, Yong Tang, Yuanyu Zhao   +9 more
doaj   +1 more source

Morphological Distribution Patterns and Neuroimmune Communication of Ganglia in Molly Fish (Poecilia sphenops, Valenciennes 1846)

Fishes, 2023
Twenty-four adult molly fish (Poecilia sphenops, Valenciennes 1846) were collected to study the morphology and distribution of ganglia using histological, immunohistochemical, and electron microscopy and focusing on their relation to the immune cells ...
Doaa M. Mokhtar, Abdelraheim Attaai, Giacomo Zaccone, Alessio Alesci, Rasha Alonaizan, Manal T. Hussein   +5 more
doaj   +1 more source

Anodal Block Of Myelinated Nerve Fibers: A Modeling Study [PDF]

[1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005
Electrical stimulation of myelinated nerve fibers was analyzed, using point sources in a simple (homogeneous) volume conductor model and a dynamic model of mammalian nerve fiber properties. The stimulus conditions resulting in anodal block of a propagating action potential were calculated as a function of electrode position.
Holsheimer, Jan, van der Heide, G.G., Struijk, J.J.   +2 more
openaire   +2 more sources

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

eLife, 2019
TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action ...
Stephen G Brohawn, Weiwei Wang, Annie Handler, Ernest B Campbell, Jürgen R Schwarz, Roderick MacKinnon   +5 more
doaj   +1 more source

Permeability of the Paranodal Junction of Myelinated Nerve Fibers [PDF]

The Journal of Neuroscience, 2010
We have used fluorescent dextran tracers to test the tightness of the paranodal junction of living or fixed myelinated fibers in mouse sciatic nerve. Both 3 and 70 kDa tracers are able to penetrate from the perinodal space symmetrically into the paranodes on either side of the node of Ranvier at a rate consistent with diffusion through an elongated ...
Amanda, Mierzwa, Seema, Shroff, Jack, Rosenbluth   +2 more
openaire   +2 more sources