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Science, 1975
Nerve growth factor (NGF) is a signaling protein [4] and growth factor implicated in a wide range of development and maintenance functions. NGF was discovered through a series of experiments in the 1950s on the development of the chick [5] nervous system.
R. Levi-Montalcini
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Nerve growth factor (NGF) is a signaling protein [4] and growth factor implicated in a wide range of development and maintenance functions. NGF was discovered through a series of experiments in the 1950s on the development of the chick [5] nervous system.
R. Levi-Montalcini
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New England Journal of Medicine, 1977
Publisher Summary Nerve growth factor (NGF) is one of an increasing number of growth factors that has been recognized as being essential for the survival and maintenance of specific types of cells. This chapter discusses the nerve growth factor from mouse submaxillary gland, the high molecular weight form of NGF (7 S NGF), the biosynthesis of NGF ...
A C, Server, E M, Shooter
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Publisher Summary Nerve growth factor (NGF) is one of an increasing number of growth factors that has been recognized as being essential for the survival and maintenance of specific types of cells. This chapter discusses the nerve growth factor from mouse submaxillary gland, the high molecular weight form of NGF (7 S NGF), the biosynthesis of NGF ...
A C, Server, E M, Shooter
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Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration
Advanced Materials, 2019The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders.
Duo Xu +22 more
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Life Sciences, 1974
Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
L F, Boyd +6 more
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Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
L F, Boyd +6 more
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Trends in Biochemical Sciences, 1993
Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase,
R A, Bradshaw +4 more
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Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase,
R A, Bradshaw +4 more
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Growth regulation by nerve growth factor
Molecular and Cellular Biochemistry, 1979Although a great deal of descriptive information has been obtained about the actions of nerve growth factor on its target tissues, its structure, its receptors, and even its biosynthesis, there is no clear understanding, as yet, of the intracellular events mediating its transcriptional involvements.
T, Ikeno, G, Guroff
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International Journal of Neuroscience, 1985
Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
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Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
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Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors
1991The pioneering investigations of Levi-Montalcini and coworkers established that nerve growth factor (NGF) is an important physiological regulator of neurons of the peripheral nervous system. No doubt in part because of the dramatic and specific effects on the sympathetic and sensory nervous system resulting from immunochemically depriving rodents of ...
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Chitosan conduits combined with nerve growth factor microspheres repair facial nerve defects
Neural Regeneration Research, 2013Microspheres containing nerve growth factor for sustained release were prepared by a compound method, and implanted into chitosan conduits to repair 10-mm defects on the right buccal branches of the facial nerve in rabbits. In addition, chitosan conduits
Hua-wei Liu +7 more
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