Results 51 to 60 of about 1,892,908 (403)

Nerve Growth Factor: A Focus on Neuroscience and Therapy

open access: yesCurrent Neuropharmacology, 2015
Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons.
L. Aloe   +3 more
semanticscholar   +1 more source

Angiogenic and Neurotrophic Effects of Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium for Erectile Dysfunction [PDF]

open access: yes, 2020
Department of Biomedical EngineeringA three-dimensional spheroid culture system to harvest conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) with high efficiency were introduced and investigated the therapeutic ...
Kim, Seul Gi
core  

Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

open access: yes, 2018
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge   +45 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Neurotrophins and neuropeptides as inflammatory mediators in case of chronic dermatosis

open access: yesVestnik Dermatologii i Venerologii, 2017
This literature review examines the role of neurotrophins and neuropeptides for the development of skin inflammatory reactions in case of chronic inflammatory dermatoses.
A. A. Kubanova   +3 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

open access: yesBMC Musculoskeletal Disorders, 2021
Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans.
Yuji Yokozeki   +9 more
doaj   +1 more source

The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma

open access: yesBioMed Research International, 2014
Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs) degeneration have been drawing more and more attention. The beneficial effects of nerve growth factor (NGF) on the glaucoma have been recently suggested, but its ...
Haitao Wang   +6 more
semanticscholar   +1 more source

Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers. [PDF]

open access: yes, 2016
PurposeWe present a case of bilateral extensive peripapillary myelinated retinal nerve fibers (MRNF) in an individual with Crouzon syndrome, an inherited form of craniosynostosis caused by overactivation of fibroblast growth factor receptor 2.
Akil, Handan   +5 more
core   +3 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

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