Results 81 to 90 of about 1,973,303 (396)

Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis [PDF]

, 2018
Neurotrophic keratitis/keratopathy (NK), a rare degenerative corneal disease, lacks effective pharmacologic therapies.1 Because NK pathology involves trigeminal nerve damage and loss of corneal innervation, nerve growth factor (NGF) is surmised to ...
Alio, Jorge, Allegretti, Marcello, Aragona, Pasquale, Benitez del Castillo, José, Bonini, Stefano, Bonini, Stefano, Bouheraoua, Nacim, Carley, Fiona, Chao, Wendy, Creuzot-Garcher, Catherine, Cursiefen, Claus, Dart, John, De La Paz, Maria, Etxebarria, Jaime, Figueiredo, Francisco, Filatori, Isabella, Fogagnolo, Paolo, Gabison, Eric, Geerling, Gerd, Hossain, Parwez, Kanna, Ramaesh, Koppen, Carina, Kruse, Friedrich, Lambiase, Alessandro, Lambiase, Alessandro, Leonardi, Andrea, Lorenz, Katrin, Malecaze, François, Mantelli, Flavio, Mastropasqua, Leonardo, Mencucci, Rita, Merayo-Lloves, Jesús, Messmer, Elisabeth, Montero, Jesus, Murta, Joaquim Neto, Nemeth, Janos, Rama, Paolo, Rama, Paolo, Rauz, Saaeha, Reinhard, Thomas, Robert, Pierre-Yves, Rolando, Maurizio, Sainz de la Maza, Maite, Szaflik, Jacek P., Torrao, Luis, Wylegala, Edward   +45 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration, and secretion of nerve growth factor

Neural Regeneration Research, 2019
After peripheral nerve injury, intraperitoneal injection of folic acid improves axon quantity, increases axon density and improves electromyography results. However, the mechanisms for this remain unclear.
Wei-Bo Kang, Yong-Jie Chen, Du-Yi Lu, Jia-Zhi Yan   +3 more
doaj   +1 more source

Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration [PDF]

, 2016
The present study aimed to evaluate the molecular mechanisms underlying combinatorial bone marrow stromal cell (BMSC) transplantation and chondroitinase ABC (Ch-ABC) therapy in a model of acellular nerve allograft (ANA) repair of the sciatic nerve gap ...
Deng, Lingxiao, Guan, Li-Xin, Jia, Hua, Li, Wen-Yuan, Liu, Gui-Bo, Liu, Yan-Cui, Wang, Ying   +6 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Urinary Biomarkers Under Investigation for Overactive Bladder Syndrome [PDF]

, 2015
Overactive bladder (OAB) is a symptom syndrome of urinary urgency, frequency, nocturia, and urge incontinence suggestive of lower urinary tract dysfunction.
Guirguis, Nayera, Heit, Michael
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]

, 1994
SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A., Bernasconi, S., Borasio, Gian Domenico, Pizzuti, A., Scarlato, G., Silani, V., Zhou, F. C.   +6 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Prediction of relative change in free nerve growth factor following subcutaneous administration of tanezumab, a novel monoclonal antibody to nerve growth factor

CPT: Pharmacometrics & Systems Pharmacology, 2023
Tanezumab is a monoclonal antibody against nerve growth factor (NGF). We investigated tanezumab pharmacokinetic (PK)‐NGF relationships and predicted the extent of systemic free NGF suppression with target‐mediated drug disposition (TMDD) modeling using ...
Satoshi Shoji, Akiyuki Suzuki, Parya Nouri, Chun‐Hua Cai, Puneet Gaitonde, Scott Marshall   +5 more
doaj   +1 more source