Results 51 to 60 of about 1,815,614 (364)

Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue

Diagnostics, 2021
Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development. Although the morbidity and mortality rate is rather significant, the pathogenesis of CDH has been studied insignificantly due to the decreased ...
Ricards Kaulins, Laura Ramona Rozite, Mara Pilmane, Aigars Petersons   +3 more
doaj   +1 more source

Nerve Growth Factor and Autoimmune Diseases

Current Issues in Molecular Biology, 2023
NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues.
Sergio Terracina, Giampiero Ferraguti, Luigi Tarani, Francesca Fanfarillo, Paola Tirassa, Massimo Ralli, Giannicola Iannella, Antonella Polimeni, Marco Lucarelli, Antonio Greco, Marco Fiore   +10 more
openaire   +5 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Potential application of let-7a antagomir in injured peripheral nerve regeneration

Neural Regeneration Research, 2023
Neurotrophic factors, particularly nerve growth factor, enhance neuronal regeneration. However, the in vivo applications of nerve growth factor are largely limited by its intrinsic disadvantages, such as its short biological half-life, its contribution ...
Qian-Qian Chen, Qian-Yan Liu, Pan Wang, Tian-Mei Qian, Xing-Hui Wang, Sheng Yi, Shi-Ying Li   +6 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair

Bioengineering, 2022
Peripheral nerve injury (PNI) is a clinical problem with high morbidity that can cause severe damage. Surgical suturing or implants are usually required due to the slow speed and numerous factors affecting repair after PNI.
Zhipeng Zeng, Yajing Yang, Junyong Deng, Muhammad Saif Ur Rahman, Chengmei Sun, Shanshan Xu   +5 more
doaj   +1 more source

Tumor microenvironment (Part I): Tissue integrity in a rat model of peripheral neural cancer [PDF]

Heliyon, Volume 10, Issue 13, e33932, July 15, 2024
ICAM-1 (intercellular adhesion molecule 1) and MPZ (myelin protein zero) are thought to be a factor in the integrity of nerve tissues. In this report, we attempted to trace the expression of ICAM-1, responsible for cell-to-cell adhesion, and of MPZ, the main constituent of myelin sheath, in malignant tissues of the sciatic nerve (SN) in inbred male ...
arxiv   +1 more source

From Single Neurons to Behavior in the Jellyfish Aurelia aurita [PDF]

eLife 2019;8:e50084, 2019
Jellyfish nerve nets provide insight into the origins of nervous systems, as both their taxonomic position and their evolutionary age imply that jellyfish resemble some of the earliest neuron-bearing, actively-swimming animals. Here we develop the first neuronal network model for the nerve nets of jellyfish.
arxiv   +1 more source

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

Immunology, 2017
Neurotrophic factors comprise a broad family of biomolecules – most of which are peptides or small proteins – that support the growth, survival and differentiation of both developing and mature neurons.
S. Skaper
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source