Results 11 to 20 of about 33,105 (266)
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
Nanotechnology Reviews, 2021 Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi +6 more
doaj +1 more source
Head-to-nerve analysis of electromechanical impairments of diffuse axonal injury [PDF]
Biomechanics and Modeling in Mechanobiology volume 18, pages
361-374(2019), 2020 The aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury are simulated at the macroscale by using a 3D head model.
arxiv +1 more source
Electro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injury [PDF]
International Journal for Numerical Methods in Biomedical
Engineering, 34 (2018) e2942, 2020 Objective: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level. Methods: The coupling is based on a thermal analogy of the neural electrical activity by using the ...
arxiv +1 more source
Characterising cellular and molecular features of human peripheral nerve degeneration
Acta Neuropathologica Communications, 2020 Nerve regeneration is a key biological process in those recovering from neural trauma. From animal models it is known that the regenerative capacity of the peripheral nervous system (PNS) relies heavily on the remarkable ability of Schwann cells to ...
Matthew B. Wilcox +6 more
doaj +1 more source
Regenerative Role of T Cells in Nerve Repair and Functional Recovery
Frontiers in Immunology, 2022 The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes.
Xiaoxuan Tang +7 more
doaj +1 more source
Journal of Neuroinflammation, 2022 Background Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pain, the role of Schwann cells and ...
Qian Wang +4 more
doaj +1 more source
Peripheral nerve injuries [PDF]
The American Journal of Surgery, 1932 Nerve injuries caused by medical interventions (Iatrogenic lesions) can complicate procedures and affect any part of the peripheral nervous system. Available data is fragmentary and little information is accessible on the overall incidence of iatrogenic nerve lesions that ranges from 1.5 to 15%.[1, 2] Major drawbacks are the limited number of patients ...
Anesti, Katerina, Caine, Paul
openaire +14 more sources
BMC Musculoskeletal Disorders, 2022 Objectives During French-door laminoplasty, a linear array transducer of IOUS was used to observe and record the spinal cord decompression. To acquire a higher-reliability method, and compare the in-observer and inter-observer reliability of two methods ...
Huachuan Wu +6 more
doaj +1 more source
The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy
Frontiers in Cellular Neuroscience, 2022 Peripheral neuropathy is a common neurological issue that leads to sensory and motor disorders. Over time, the treatment for peripheral neuropathy has primarily focused on medications for specific symptoms and surgical techniques.
Qian Wang +8 more
doaj +1 more source