Results 51 to 60 of about 3,082,625 (411)

Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis

open access: yesFrontiers in Molecular Biosciences, 2023
Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang   +17 more
doaj   +1 more source

Bilateral triad of persistent median artery, a bifid median nerve and high origin of its palmar cutaneous branch. A case report and clinical implications [PDF]

open access: yes, 2016
We report the association of a persistent median artery, a bifid median nerve with a rare very high origin palmar cutaneous branch, presenting bilaterally in the upper limb of a 75-year-old female cadaver.
Ariyo, Olutayo, Shea, John
core   +2 more sources

Nerve injuries

open access: yesMedical Clinics of North America, 1994
Sports medicine physicians should be able to recognize and manage peripheral nerve injuries in athletes. Most often, the injury is a result of repetitive microtrauma, linking peripheral nerve injury to other musculoskeletal injuries in athletes. As with other musculoskeletal injuries, rest and a modification of the athlete's regimen often lead to ...
openaire   +2 more sources

Tissue engineering for the repair of peripheral nerve injury

open access: yesNeural Regeneration Research, 2019
Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering.
Pei-Xun Zhang   +7 more
semanticscholar   +1 more source

Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury

open access: yesScientific Reports, 2017
Ischemic stroke and the following reperfusion, an acute therapeutic intervention, can cause irreversible brain damages. However, the underlying pathological mechanisms are still under investigation.
Jinlong Shi   +7 more
doaj   +1 more source

Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

open access: yesBMC Chemistry, 2023
As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers.
Ling Yu   +6 more
doaj   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

open access: yes, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves   +7 more
core   +3 more sources

Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation

open access: yesNeural Regeneration Research, 2019
In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of ...
Gonghai Han   +6 more
semanticscholar   +1 more source

Early phrenic motor neuron loss and transient respiratory abnormalities following unilateral cervical spinal cord contusion [PDF]

open access: yes, 2013
Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in ...
Adriaens, Dominique   +8 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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