Results 51 to 60 of about 1,694,794 (371)
Intradiscal injection for the management of low back pain
JOR Spine, 2022 Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang +5 more
doaj +1 more source
Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies
Antioxidants, 2021 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive loss of motor neurons, leading to a fatal paralysis. According to whether there is a family history of ALS, ALS can be roughly divided into two types: familial and ...
Xiaoming Yang +9 more
doaj +1 more source
Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]
arXiv, 2022 Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv
Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]
Neural Regen. Res. 2015;10(3):352-4, 2015 Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv +1 more source
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Frontiers in Bioengineering and Biotechnology, 2019 Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the ...
Cristiana R. Carvalho +2 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy.
Ziwei Huang +8 more
doaj +1 more source
Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study
Frontiers in Physiology, 2023 Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation
Zhengya Zhu +18 more
doaj +1 more source
Neuronal Growth and Formation of Neuron Networks on Directional Surfaces [PDF]
Biomimetics 6(2), 41 (2021), 2022 The formation of neuron networks is a process of fundamental importance for understanding the development of the nervous system and for creating biomimetic devices for tissue engineering and neural repair. The basic process that controls the network formation is the growth of an axon from the cell body and its extension towards target neurons.
arxiv
Antioxidants, 2021 Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang +11 more
doaj +1 more source
Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair
Advanced Healthcare Materials, 2018 Repair of peripheral nerve injuries depends upon complex biology stemming from the manifold and challenging injury‐healing processes of the peripheral nervous system.
Adrián Magaz +5 more
semanticscholar +1 more source