Results 51 to 60 of about 315,123 (306)

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Plastic compression of collagen: development and assessment of a new biomaterial in nerve repair [PDF]

, 2005
Nerve reconstruction is a surgical challenge. Current neural conduits provide sub-optimal clinical results. We have developed a device from a composite material comprising a fibronectin core and a collagen outer layer, using collagen made by a new ...
Ashraff, S, Brown, R.A., Phillips, J.B.
core  

Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]

, 2016
Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne, Panagiotou, Nikolaos, Selman, Colin, Shiels, Paul G.   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study

Frontiers in Physiology, 2023
Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation
Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Tao Tang, Tao Tang, Fuan Wang, Fuan Wang, Hongkun Chen, Jiaxiang Zhou, Chengkai Lin, Guoliang Chen, Jianmin Wang, Jianfeng Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +18 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Medical implantable devices for the controlled release of anti-TGF-beta1 in the repair of peripheral nerve injuries [PDF]

, 2004
The development of novel bioartificial nerve grafts which release soluble therapeutic agents, shows great promises guiding the extension of the injured axons and optimizing and improving the degree and specificity of neural outgrowth.
Brown, R.A., Caneva Soumetz, F., Giacomini, M., Phillips, J.B., Ruggiero, C.   +4 more
core  

Treatment of peroneal nerve injuries with simultaneous tendon transfer and nerve exploration [PDF]

, 2014
Background Common peroneal nerve palsy leading to foot drop is difficult to manage and has historically been treated with extended bracing with expectant waiting for return of nerve function.
Cederna, Paul, Dahl, William, Fuchs, Daniel, Ho, Bryant, Kadakia, Anish R, Khan, Zubair, Kung, Theodore A, Ochenjele, George, Switaj, Paul J   +8 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source