Results 61 to 70 of about 311,832 (302)
Plastic compression of collagen: development and assessment of a new biomaterial in nerve repair [PDF]
, 2005 Nerve reconstruction is a surgical challenge. Current neural conduits provide sub-optimal clinical results. We have developed a device from a composite material comprising a fibronectin core and a collagen outer layer, using collagen made by a new ...
Ashraff, S, Brown, R.A., Phillips, J.B.
core
Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing [PDF]
, 2003 One of the most devastating effects of damage to the upper spinal cord is the loss of the ability to breathe; patients suffering these injuries can be kept alive only with assisted ventilation. No known method for repairing these injuries exists.
Decherchi, P., Li, Y., Raisman, G.
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Endogenous musculoskeletal tissue engineering - a focused perspective [PDF]
, 2012 Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells ...
Adam, Clayton
core +2 more sources
Considerations in Nerve Repair [PDF]
Baylor University Medical Center Proceedings, 2003 (2003). Considerations in Nerve Repair. Baylor University Medical Center Proceedings: Vol. 16, No. 2, pp. 152-156.
Larry M, Wolford, Eber L L, Stevao
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study
Frontiers in Physiology, 2023 Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation
Zhengya Zhu +18 more
doaj +1 more source
Engineering peripheral nerve repair [PDF]
Current Opinion in Biotechnology, 2013 Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy.
Laura M, Marquardt +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
An examination of walking track analysis footprints of right-side unoperated limbs in rats prior to and following peripheral nerve injury and PEG fusion repair [PDF]
, 2018 Peripheral nerve injury can result in long-lasting functional deficits in humans due to mammals’ limited axon regenerative capacity. PEG fusion is a defined technique that fuses injured axons, resulting in morphological and electrophysiological ...
Jagannath, Karthik
core +1 more source