Results 51 to 60 of about 311,832 (302)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Correlated disorder in myelinated axons orientational geometry and structure

, 2017
While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following neurological ...
Bianconi, Antonio, Campi, Gaetano, Di Gioacchino, Michael, Poccia, Nicola   +3 more
core   +1 more source

Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity [PDF]

, 2017
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis.
Aditya Shivane, Alexander Schulz, Ammoun, Arthur-Farraj, Asthagiri, Baptista, Bethany Gray, Cooper, Crawford, Dahlin, David B. Parkinson, de Vries, Denisenko, Doddrell, Domènech-Estévez, Dun, Duojia Pan, Feltri, Fey, Fischer, Fischer, Fontana, Gehlhausen, Georgina Mortimer, Giovannini, Goebbels, Goebbels, Hanemann, Harrisingh, Hayashi, Helen Morrison, Hilton, Ishii, James Russell, Jessen, Jessen, Kang, Katherine North, Kim, Kuhn, Li, Melissa Pirie, Myers, Nailing Zhang, Napoli, Painter, Parkinson, Parkinson, Parkinson, Philip Edwards, Poitelon, Pratt-Hyatt, Robin D.S. Doddrell, Schulz, Schulz, Schulz, Schulz, Shao, Sharghi-Namini, Sheridan L. Roberts, Shimomura, Thomas Mindos, Tofaris, Truett, Tumaneng, Xin-peng Dun, Xu, Yang, Yang, Yu, Zhang, Zhao   +71 more
core   +3 more sources

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Spectrum and signals of medication-associated cognitive disorder: a comprehensive disproportionality analysis with cross-database validation

Frontiers in Pharmacology
ObjectiveThe clinical risk of cognitive disorders linked to various drugs is not well-defined. This study aimed to identify medications with notable signals for drug-related cognitive disorders and evaluate whether their US Food and Drug Administration ...
Hao Wen, Yajie Dong, Ruiting Wang
doaj   +1 more source

Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy Through Negative Regulation of Pro-inflammatory Cytokine

Frontiers in Physiology, 2019
Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside is a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property.
Changyue Wu, Changyue Wu, Longhai Tang, Xuejun Ni, Tongtong Xu, Qingqing Fang, Lai Xu, Wenjing Ma, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts [PDF]

, 2016
Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal regeneration across long defects (>3 cm). Causes for this deficiency are poorly understood.
Ee, Xueping, Hoben, Gwendolyn M, Hunter, Daniel A, Mackinnon, Susan E, Moore, Amy M, Pan, Deng, Poppler, Louis H, Schellhardt, Lauren, Snyder-Warwick, Alison K, Stewart, Sheila A, Wood, Matthew D, Yan, Ying   +11 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation

Antioxidants, 2021
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun   +11 more
doaj   +1 more source